Rosuvastatin Impurity 162 CAS 488798-40-9
| CAS No. | 488798-40-9 |
| Molecular Formula | C22H21FN2O5S |
| Molecular Weight | 444.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Rosuvastatin Impurity 162.
Rosuvastatin Impurity 162 (CAS 488798-40-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H21FN2O5S and a molecular weight of 444.48 g/mol.
Rosuvastatin Impurity 162 (C22H21FN2O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rosuvastatin Impurity 162 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21FN2O5S |
| Molecular Weight | 444.48 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 131 (CAS 1246665-85-9)
- Rosuvastatin Impurity 160 (CAS CATO-C4X-1169160)
- Rosuvastatin Impurity 134 (CAS 1797419-58-9)
- Rosuvastatin Impurity 260 (CAS CATO-C4X-1169260)
- Rosuvastatin Impurity 48 (CAS CATO-C4X-116948)
- Rosuvastatin Impurity 180 (CAS CATO-C4X-1169180)
- Rosuvastatin Impurity 88 (CAS CATO-C4X-116988)
- Rosuvastatin Impurity 74 (CAS 615263-62-2)
Recommended Standards
- Azilsartan Impurity 85 (CAS 2133408-92-9)
- Candesartan Cilexetil EP Impurity G-d4 (CAS 1346604-70-3)
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- Docetaxel Impurity 25 (CAS CATO-C4X-161925)
- Furosemide Impurity 25 (CAS CATO-C4X-140235)
- Josamycin Impurity 11 (CAS 31674-19-8)
- Sertraline EP Impurity A (CAS 79836-45-6)
- 4-Fluoro-3-(methoxymethyl)-1-benzothiophene-2-carboxylic acid (CAS 854357-47-4)
- 2-Methoxy-2-(5-methylthiophen-2-yl)acetonitrile (CAS 1484301-61-2)
- 1-Methyl-5-(pyrrolidin-3-yl)-1H-imidazole (CAS 1507372-84-0)
- N-(4H-1,2,4-triazol-4-yl)-3-(trifluoromethyl)benzamide (CAS 478046-01-4)
- N-Hydroxy-2-(1-pyrrolidinyl)-benzenecarboximidamide (CAS 1021243-91-3)
- 1-(2-Methylphenyl)cyclohexan-1-ol (CAS 6957-09-1)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
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