Afoxolaner impurity 7 CAS CATO-C4X-31377
| CAS No. | CATO-C4X-31377 |
| Molecular Formula | C22H12ClF6NO3 |
| Molecular Weight | 487.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Afoxolaner impurity 7 (CAS CATO-C4X-31377), a pharmacopoeial impurity reference standard (molecular formula C22H12ClF6NO3, MW 487.78 g/mol) used for the identification and quantification of trace impurities in APIs.
Afoxolaner impurity 7 (C22H12ClF6NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H12ClF6NO3 |
| Molecular Weight | 487.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Afoxolaner Standards
- Afoxolaner Impurity 28 (CAS 1308362-48-2)
- Afoxolaner Impurity 18 (CAS CATO-C4X-313718)
- Afoxolaner Impurity 13 (CAS 1125727-10-7)
- Afoxolaner Impurity 23 (CAS CATO-C4X-313723)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
- Afoxolaner Impurity 16 (CAS 1190862-76-0)
- Afoxolaner impurity 6 (CAS CATO-C4X-31376)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
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