Estriol impurity 23 CAS 1247-47-8
| CAS No. | 1247-47-8 |
| Molecular Formula | C22H26O5 |
| Molecular Weight | 370.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Estriol impurity 23.
Estriol impurity 23 (CAS 1247-47-8) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26O5 and a molecular weight of 370.44 g/mol.
Structurally, Estriol impurity 23 (C22H26O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 370.44 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26O5 |
| Molecular Weight | 370.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Estriol Standards
- Estriol Impurity 19 (CAS CATO-C4X-163719)
- Estriol 3-Sulfate (CAS 481-95-8)
- Estriol 16,17-Diacetate (CAS 805-26-5)
- Estriol Impurity 18 (CAS CATO-C4X-163718)
- Estriol Impurity 14 (CAS 1497406-77-5)
- Estriol 3-Benzyl Ether (CAS 18650-87-8)
- Estriol Impurity 21 (CAS CATO-C4X-163721)
- Estriol 3-Succinate (CAS 47575-61-1)
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