Ramipril EP Impurity K CAS 108736-10-3
| CAS No. | 108736-10-3 |
| Molecular Formula | C21H26N2O4 |
| Molecular Weight | 370.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 370.44 g/mol gives Ramipril EP Impurity K distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ramipril EP Impurity K (CAS 108736-10-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H26N2O4 and a molecular weight of 370.44 g/mol.
The molecular framework of Ramipril EP Impurity K (C21H26N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H26N2O4 |
| Molecular Weight | 370.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Ramipril Standards
- Ramipril EP Impurity M (CAS 2743-38-6)
- Ramipril EP Impurity E (CAS 87269-97-4)
- Ramipril EP Impurity D (CAS 108731-95-9)
- Ramipril EP Impurity A (CAS 108313-11-7)
- Ramipril EP Impurity L (CAS 1309040-96-7)
- Ramipril EP Impurity L(mixture) (CAS CATO-C4X-174412)
- Ramipril Impurity 1 (CAS CATO-C4X-17441)
- Ramipril (CAS 87333-19-5)
Recommended Standards
- Estriol impurity 23 (CAS 1247-47-8)
- Vincamine impurity 5 (CAS 51442-60-5)
- Estriol Impurity 19 (CAS CATO-C4X-163719)
- Peramivir impurity 121 (CAS CATO-C4X-1833121)
- Capecitabine EP Impurity A (CAS 66335-38-4)
- Moxifloxacin Impurity 44 (CAS 112811-70-8)
- Ibrutinib Impurity 22 (CAS CATO-C4X-106422)
- 1-Methyl-5-((methylamino)methyl)pyrrolidin-2-one (CAS 479065-35-5)
- Mometasone Furoate Impurity 26 (CAS CATO-C4X-170426)
- Ethyl 2-methyl-3-oxo-3-(thiophen-2-yl)propanoate (CAS 166180-39-8)
- 2-(3-Methyl-1,2,4-oxadiazol-5-yl)benzaldehyde (CAS 879896-54-5)
- 3-methyl-1-(pyridin-2-ylmethyl)piperidin-4-amine (CAS 1250301-26-8)
- 1-(Phenylsulfonyl)-3-pyrrolidinecarboxylic Acid (CAS 1384643-33-7)
- Semaglutide impurity 57 (CAS 2773558-06-6)
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