Paroxetine EP Impurity I CAS 125224-43-3
| CAS No. | 125224-43-3 |
| Molecular Formula | C12H16FNO |
| Molecular Weight | 209.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Paroxetine EP Impurity I (CAS 125224-43-3), a pharmacopoeial impurity reference standard (molecular formula C12H16FNO, MW 209.26 g/mol) used for the identification and quantification of trace impurities in APIs.
Paroxetine EP Impurity I (C12H16FNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H16FNO |
| Molecular Weight | 209.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Paroxetine Standards
- Paroxetine Impurity N1 (Mixture of Diastereomers) (CAS 216690-19-6)
- Paroxetine Impurity 21 (CAS 176022-03-0)
- Paroxetine Impurity 8 (CAS CATO-C4X-10358)
- Paroxetine Impurity 19 (CAS 318279-38-8)
- Paroxetine impurity 20 (CAS 389573-45-9)
- Paroxetine Impurity 24 (CAS 105812-81-5)
- Paroxetine Impurity 43 (CAS 100332-20-5)
- Paroxetine Impurity 53 (CAS 109887-53-8)
Recommended Standards
- 98-42-0 3-Amino-4-methoxybenzenesulphonic acid Benzenesulfonic acid, 3-amino-4-methoxy- Metanilic acid, 4-methoxy- (8CI) 3-Amino-4-methoxybenzenesulfonic acid o-Anisidine-p-sulfonic acid o-Anisidine-4-sulfonic acid EINECS 202-667-5 2-Methoxyaniline-5-sulfonic acid 4-Methoxymetanilic acid 2-Methoxy-5-sulfoaniline NSC 74459 EC 202-667-5 (CAS 98-42-0)
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- Upadacitinib Impurity 28 (CAS 1310726-59-0)
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Why CATO?
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