Paroxetine impurity 20 CAS 389573-45-9
| CAS No. | 389573-45-9 |
| Molecular Formula | C13H18FNO |
| Molecular Weight | 223.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 223.29 g/mol gives Paroxetine impurity 20 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Paroxetine impurity 20 (CAS 389573-45-9, C13H18FNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Paroxetine impurity 20 (C13H18FNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Paroxetine impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H18FNO |
| Molecular Weight | 223.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Paroxetine Standards
- Paroxetine Impurity 19 (CAS 318279-38-8)
- Paroxetine Impurity 24 (CAS 105812-81-5)
- Paroxetine Impurity 43 (CAS 100332-20-5)
- Paroxetine Impurity 53 (CAS 109887-53-8)
- Paroxetine Impurity 62 (CAS 100332-12-5)
- Paroxetine Impurity 7 (CAS CATO-C4X-10357)
- Paroxetine Impurity 22 (CAS 127017-78-1)
- Paroxetine Impurity N1 (Mixture of Diastereomers) (CAS 216690-19-6)
Recommended Standards
- 946725-20-8 4-{[(3-Fluorophenyl)methoxy]methyl}piperidine DTXSID80649875 (CAS 946725-20-8)
- N-methyl-2-(2-phenylacetyl)hydrazine-1-carbothioamide (CAS 51291-26-0)
- N-isopropyl-6-methylimidazo[2,1-b]thiazole-5-carboxamide (CAS 478066-31-8)
- N-(But-3-yn-2-yl)-4-methylbenzenesulfonamide (CAS 491879-61-9)
- Carbamazepine Impurity 39 (CAS 53003-61-5)
- Ezetimibe Impurity 72 (CAS CATO-C4X-109872)
- Baricitinib Impurity 105 (CAS CATO-C4X-2260105)
- Sumatriptan Impurity 17 (CAS 88919-50-0)
- 4-(4-Chlorophenyl)-N-methylthiazol-2(3H)-imine (CAS 21344-78-5)
- 2-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonitrile (CAS 1515319-88-6)
- 2-(Furan-2-yl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid (CAS 917089-63-5)
- 3-(2-Oxo-2-phenylethyl)-5,6-dihydropyrazin-2(1h)-one (CAS 1821-59-6)
- 4-amino-1,7-dimethyl-pyrazolo[4,3-c][1,8]naphthyridine-8-carboxylic acid (CAS 2790570-00-0)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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