tert-Butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate CAS 1255666-39-7
| CAS No. | 1255666-39-7 |
| Molecular Formula | C11H19F2NO3 |
| Molecular Weight | 251.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
tert-Butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate (CAS 1255666-39-7), molecular formula C11H19F2NO3 and molecular weight 251.27 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, tert-Butyl 5,5-difluoro-2-(hydroxymethyl)piperidine-1-carboxylate (C11H19F2NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 251.27 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H19F2NO3 |
| Molecular Weight | 251.27 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 1-((3-((Trifluoromethyl)thio)pyrrolidin-1-yl)methyl)-1H-imidazole (CAS 1206524-57-3)
- 1-Boc-5,5-difluoro-3-(hydroxymethyl)piperidine (CAS 1262412-64-5)
- 4-Amino-6-(4-nitrophenyl)-1,6-dihydro-1,3,5-triazine-2-thiol (CAS 1142208-01-2)
- 6-Amino-n-(pyrimidin-2-yl)pyridine-3-sulfonamide (CAS 1281520-31-7)
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