5,5-difluoropiperidin-2-one CAS 1255666-50-2
| CAS No. | 1255666-50-2 |
| Molecular Formula | C5H7F2NO |
| Molecular Weight | 135.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5,5-difluoropiperidin-2-one (C5H7F2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
5,5-difluoropiperidin-2-one (CAS 1255666-50-2) is a high-purity analytical reference standard with the molecular formula C5H7F2NO and a molecular weight of 135.11 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H7F2NO |
| Molecular Weight | 135.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related difluoropiperidin Standards
- 3,3-Difluoropiperidin-2-one (CAS 1206540-41-1)
- 4,4-Difluoropiperidin-2-one (CAS 1255666-74-0)
- 3,3-difluoropiperidin-4-one (CAS 1283720-75-1)
- 5,5-Difluoropiperidin-3-one (CAS 1304192-58-2)
- (3R)-5,5-difluoropiperidin-3-amine (CAS 2580094-38-6)
- (3S)-5,5-difluoropiperidin-3-amine (CAS 2580114-26-5)
- 3,3-Difluoropiperidin-1-amine (CAS 935260-59-6)
- 4,4-Difluoropiperidin-1-amine (CAS 811441-26-6)
Recommended Standards
- 2,2-Difluoropent-4-enamide (CAS 118337-63-6)
- 7,7-Difluoro-2-oxa-5-azabicyclo[4.1.0]heptane (CAS 1258640-26-4)
- Dichlorodimethyl-d (CAS 80311-36-0)
- 2,2-Difluoro-1-Methylcyclopropanecarboxamide (CAS 128230-75-1)
- 3-Chloro-5-cyclopropyl-1,2,4-thiadiazole (CAS 1597081-85-0)
- 9-Chloro-2-methoxyacridine (CAS 16492-13-0)
- (S)-2-acetamido-3-(4-isopropoxyphenyl)propanoic acid (CAS 92501-74-1)
- (2,4-Bis(trifluoromethoxy)phenyl)boronic acid (CAS 511521-83-8)
- N-methyltetrahydro-2H-pyran-4-sulfonamide (CAS 1249039-87-9)
- (4-(Pyrrolidin-1-yl)phenyl)methanamine (CAS 114365-04-7)
- tributyl(cyclopropylethynyl)stannane (CAS 254108-69-5)
- [6-[2-(Trifluoromethyl)phenyl]3-pyridyl]methanol (CAS 220455-42-5)
- Lesinurad Impurity 35 (CAS 1533519-86-6)
- Met(O)14-Exenatide trifluoroacetate salt (CAS 1678417-38-3)
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