1-(4-Chloro-3,5-difluorophenyl)ethan-1-one CAS 1256352-85-8
| CAS No. | 1256352-85-8 |
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(4-Chloro-3,5-difluorophenyl)ethan-1-one.
1-(4-Chloro-3,5-difluorophenyl)ethan-1-one (CAS 1256352-85-8) is a high-purity analytical reference standard with the molecular formula C8H5ClF2O and a molecular weight of 190.57 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 1-(4-Chloro-3,5-difluorophenyl)ethan-1-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(4-Chloro-3,5-difluorophenyl)ethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O |
| Molecular Weight | 190.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4'-Chloro-2',6'-difluoroacetophenone (CAS 1017777-45-5)
- 1-(2-Chloro-4,5-difluorophenyl)ethanone (CAS 121872-94-4)
- 2-(2-Chloro-3,6-difluorophenyl)acetaldehyde (CAS 1256477-62-9)
- 2-(3-Chloro-2,6-difluorophenyl)acetaldehyde (CAS 1256479-70-5)
- 1-(6-Chloro-2,3-difluorophenyl)ethan-1-one (CAS 1373920-86-5)
- 1-(3-Chloro-2,4-difluorophenyl)ethanone (CAS 154258-06-7)
- 5-Chloro-2-(difluoromethyl)benzaldehyde (CAS 1554368-81-8)
- 6-Chloro-2,4-difluoro-3-methylbenzaldehyde (CAS 1706435-05-3)
Recommended Standards
- 121639-61-0 (3,4-Difluorophenyl)acetyl chloride DTXSID60562255 (CAS 121639-61-0)
- Voriconazole Impurity 60 (CAS 116622-90-3)
- 2,4-Difluoro-5-methylbenzoyl chloride (CAS 1263376-87-9)
- 2,4-Difluoro-3-methylbenzoyl chloride (CAS 112857-70-2)
- 5-Phenoxy-n-valeric acid (CAS 7170-40-3)
- 6-((3,5-Dimethoxyphenyl)amino)-2,3-dihydroindolizin-5(1H)-one (CAS 612065-08-4)
- 7-Chloro-3-(3,4-dimethylbenzenesulfonyl)-N-(3-methoxyphenyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 904584-39-0)
- (4-(4-Nitrophenoxy)phenyl)methanol (CAS 926641-05-6)
- 4-(Naphthalen-1-yloxy)butanoic acid (CAS 16563-45-4)
- 1,7,8-Trichlorodibenzo-p-dioxin (CAS 82306-65-8)
- N-(2-Bromo-4,5-dimethyl-phenyl)-2-chloro-acetamide (CAS 592474-64-1)
- 2-Amino-3-cyano-6-(difluoromethyl)isonicotinic acid (CAS 1805930-38-4)
- 4-(1-Cyclopentyl-1H-pyrazol-5-yl)piperidine (CAS 1707359-97-4)
- Liraglutide Impurity 28 (CAS CATO-C4X-199228)
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