Betamethasone impurity 61 CAS 1257544-84-5
| CAS No. | 1257544-84-5 |
| Molecular Formula | C22H27FO5 |
| Molecular Weight | 390.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Betamethasone impurity 61 (CAS 1257544-84-5, C22H27FO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Betamethasone impurity 61 (C22H27FO5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Betamethasone impurity 61 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H27FO5 |
| Molecular Weight | 390.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone impurity 100 (CAS CATO-C4X-1437100)
- Betamethasone impurity 49 (CAS CATO-C4X-143749)
- Betamethasone Impurity 57 (CAS 1257544-85-6)
- Betamethasone Impurity 124 (CAS 947382-36-7)
- Betamethasone Impurity 22 (CAS 2990-65-0)
- Betamethasone EP Impurity H (CAS 185613-71-2)
- Betamethasone Impurity 117 (CAS CATO-C4X-1437117)
- Betamethasone Impurity 145 (CAS CATO-C4X-1437145)
Recommended Standards
- Tafluprost Impurity 2 (CAS CATO-C4X-21632)
- Isodecyl Diphenyl Phosphate (CAS 29761-21-5)
- Fluticasone Impurity N10 (CAS 23961-95-7)
- 21-Dehydro Dexamethasone (CAS 2964-79-6/4619-61-8)
- Cefcapene Impurity 74 (CAS CATO-C4X-182474)
- Enarodustat Impurity 21 (CAS CATO-C4X-322821)
- Arbidol Impurity 19 (CAS CATO-C4X-112919)
- Methyl 3-methylimidazo[1,5-a]pyrazine-1-carboxylate (CAS 1341040-37-6)
- 4-Methyl-2-(methylthio)thiophen-3-amine (CAS 88246-46-2)
- (S)-Benzoic acid 7R-methyl-1R-(1R,4R,5-trimethyl-hex-2-enyl)-octahydro-inden-4-yl ester (CAS 68702-86-3)
- 2-Methoxy-6-(3-phenyl-propyl)-benzoic acid methyl ester (CAS 365543-11-9)
- N-(9,9-dimethyl-9H-fluoren-4-yl)-9,9-dimethyl-9H-fluoren-2-amine (CAS 1644054-07-8)
- 6-methoxybenzofuran (CAS 50551-63-8)
- MOTS-c Peptide (CAS 1627580-64-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com