4-Nitro-3-(trifluoromethoxy)phenol CAS 1260654-90-7
| CAS No. | 1260654-90-7 |
| Molecular Formula | C7H4F3NO4 |
| Molecular Weight | 223.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Nitro-3-(trifluoromethoxy)phenol (CAS 1260654-90-7), molecular formula C7H4F3NO4 and molecular weight 223.11 g/mol, is a CATO reference standard with documented purity and traceability.
4-Nitro-3-(trifluoromethoxy)phenol (C7H4F3NO4) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4F3NO4 |
| Molecular Weight | 223.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Nitro Standards
- 2-Nitro-5-(trifluoromethoxy)phenol (CAS 1197236-32-0)
- 3-Nitro-4-(trifluoromethoxy)phenol (CAS 1214332-23-6)
- 2-Nitro-6-(trifluoromethoxy)phenol (CAS 1261445-46-8)
- 4-Nitro-2-(trifluoromethoxy)phenol (CAS 1261753-93-8)
- 2-Nitro-4-(trifluoromethoxy)phenol (CAS 129644-56-0)
- 5-Nitro-2-(trifluoromethoxy)pyridin-4-amine (CAS 1361741-17-4)
- 1-Nitro-3-(1,2,2,2-tetrafluoroethyl)benzene (CAS 612844-88-9)
- 2-Nitro-4-(trifluoromethyl)benzene-1-thiol (CAS 14371-82-5)
Recommended Standards
- 1-Bromo-2-(2-methoxyethoxy)cyclopentane (CAS 1249466-66-7)
- tert-Butyl 3-bromobutanoate (CAS 1268837-93-9)
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- 4-(Bromomethyl)-4-ethoxyoxane (CAS 111511-48-9)
- methyl 3,4-difluoro-1H-pyrrole-2-carboxylate (CAS 160561-79-5)
- 7-Fluoro-6-methoxy-1,2,3,4-tetrahydroisoquinoline (CAS 1046816-59-4)
- 1-(4-cyanophenyl)cyclopropane-1-carboxylic acid (CAS 1094478-22-4)
- Estradiol Impurity 27 (CAS CATO-C4X-163627)
- Barbituric Acid Impurity 19 (CAS 65959-54-8)
- 1-(1-Ethyl-1H-benzo[d]imidazol-2-yl)piperidine-3-carboxylic acid (CAS 919037-44-8)
- 4-FLuoro-2'-(trifluoromethyl)biphenyl-3-carboxylic acid methyl ester (CAS 1261788-37-7)
- 5-(Isopropylthio)spiro[2.3]hexane-5-carboxylic acid (CAS 1484582-84-4)
- (1-Cyclohexylpiperidin-4-yl)methanamine dihydrochloride (CAS 1268990-75-5)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
Why CATO?
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