5-Bromo-3-(chloromethyl)pyridine-2-amine hydrochloride CAS 1260902-03-1
| CAS No. | 1260902-03-1 |
| Molecular Formula | C6H6BrClN2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Bromo-3-(chloromethyl)pyridine-2-amine hydrochloride is closely related to a nitrile group, chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Bromo-3-(chloromethyl)pyridine-2-amine hydrochloride (CAS 1260902-03-1), molecular formula C6H6BrClN2HCl and molecular weight 257.94 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Bromo-3-(chloromethyl)pyridine-2-amine hydrochloride (C6H6BrClN2HCl) is characterized by a nitrile group, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6BrClN2 HCl |
| Molecular Weight | 257.94 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
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Recommended Standards
- 3-(4-Chlorobenzyl)-6-((3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one (CAS 1040653-07-3)
- Amicoumacin B (CAS 77674-99-8)
- Decane-1,10-diyl diacetate (CAS 26118-61-6)
- Ethyl 3-amino-3-(4-butoxyphenyl)propanoate hydrochloride (CAS 1049735-47-8)
- Plerixafor Impurity 29 8HCl (CAS CATO-C4X-113329)
- 6-Bromo-2,3-difluoro-4-hydroxybenzaldehyde (CAS 2010955-48-1)
- 2-(3,5-Diphenyl-1H-pyrazol-1-yl)acetic acid (CAS 93323-67-2)
- 7-Methoxybenzofuran-2-carboxamide (CAS 53020-46-5)
- 2-(2,4-Dimethylphenyl)-6,8-dimethylquinoline-4-carboxylic acid (CAS 445260-11-7)
- Hexapeptide-9 (CAS 1228371-11-6)
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