5-Chloro-6-(3-(trifluoromethoxy)phenyl)nicotinic acid CAS 1261485-75-9
| CAS No. | 1261485-75-9 |
| Molecular Formula | C13H7ClF3NO3 |
| Molecular Weight | 317.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-6-(3-(trifluoromethoxy)phenyl)nicotinic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Chloro-6-(3-(trifluoromethoxy)phenyl)nicotinic acid (CAS 1261485-75-9), molecular formula C13H7ClF3NO3 and molecular weight 317.65 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 5-Chloro-6-(3-(trifluoromethoxy)phenyl)nicotinic acid (C13H7ClF3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 317.65 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-6-(3-(trifluoromethoxy)phenyl)nicotinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H7ClF3NO3 |
| Molecular Weight | 317.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)benzoic acid (CAS 105626-87-7)
- 4-Chloro-6-(4-trifluoromethoxyphenylamino)pyrimidine-5-carbaldehyde (CAS 1160701-79-0)
- 2-Chloro-5-(3-(trifluoromethoxy)phenyl)nicotinic acid (CAS 1258616-79-3)
- 2-Chloro-5-(3-(trifluoromethoxy)phenyl)isonicotinic acid (CAS 1258621-11-2)
- 2-Chloro-5-(4-(trifluoromethoxy)phenyl)isonicotinic acid (CAS 1261586-34-8)
- 2-Chloro-5-(4-(trifluoromethoxy)phenyl)nicotinic acid (CAS 1261763-21-6)
- 5-Chloro-2-[3-(trifluoromethyl)-phenoxy]nicotinic acid (CAS 1338494-58-8)
- 2-Chloro-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)benzoic acid (CAS 1456213-79-8)
Recommended Standards
- 2-(5-Bromothiophen-2-yl)-4-chloro-5-ethyl-6-methylpyrimidine (CAS 915084-50-3)
- 1-(4-Bromo-2-chlorobenzyl)-4-ethylpiperazine (CAS 1704074-23-6)
- 2,4,6-Trichlorophenyl 1-butanesulfonate (CAS 1171919-49-5)
- 1-(5-Bromo-2-chlorobenzyl)-4-ethylpiperazine (CAS 1704074-47-4)
- 7-Vinyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 1824471-86-4)
- 1,3-Dimethyl-2-fluoroimidazolinium iodide (CAS 1029633-62-2)
- (3-Aminopyrrolidin-1-yl)(4-methoxyphenyl)methanone hydrochloride (CAS 1579234-40-4)
- 3-phenyl-2,3-dihydro-1H-indole (CAS 62236-19-5)
- Methyl 6-hydroxycyclohex-1-ene-1-carboxylate (CAS 865780-25-2)
- 4-(4-Propoxyphenyl)thiazol-2-amine (CAS 15850-30-3)
- 3-Bromo-8-methylquinolin-6-amine (CAS 858467-31-9)
- 1-(2-Hydroxyphenyl)-2-(1H-imidazol-1-yl)ethanone (CAS 85928-32-1)
- 2-((2R)-1-((benzyloxy)carbonyl)-2-methylpiperidin-4-yl)acetic acid (CAS 2306259-19-6)
- Fibrinopeptide B (human) (CAS 36204-23-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com