2-(Difluoromethoxy)-5-fluoro-4'-(trifluoromethyl)biphenyl CAS 1261493-82-6
| CAS No. | 1261493-82-6 |
| Molecular Formula | C14H8F6O |
| Molecular Weight | 306.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Difluoromethoxy)-5-fluoro-4'-(trifluoromethyl)biphenyl.
CATO supplies 2-(Difluoromethoxy)-5-fluoro-4'-(trifluoromethyl)biphenyl (CAS 1261493-82-6), a certified reference material (molecular formula C14H8F6O, MW 306.20 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Difluoromethoxy)-5-fluoro-4'-(trifluoromethyl)biphenyl (C14H8F6O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8F6O |
| Molecular Weight | 306.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 4-(Difluoromethoxy)-2-fluoro-4'-(trifluoromethyl)-1,1'-biphenyl (CAS 1261440-14-5)
- 4'-(Difluoromethoxy)-3'-fluoro-2-(trifluoromethyl)-1,1'-biphenyl (CAS 1261493-86-0)
- 4-(Difluoromethoxy)-2-fluoro-2'-(trifluoromethyl)-1,1'-biphenyl (CAS 1261745-12-3)
- 2-(Difluoromethoxy)-3-fluoro-2'-(trifluoromethyl)biphenyl (CAS 1261771-25-8)
- 4-(Difluoromethoxy)-3-fluoro-4'-(trifluoromethyl)-1,1'-biphenyl (CAS 1261822-87-0)
- 2-(Difluoromethoxy)-5-fluoro-2'-(trifluoromethyl)biphenyl (CAS 1261887-76-6)
- 2-(4-(Difluoromethoxy)-2,3-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1628442-57-8)
- 2-(4-(Difluoromethoxy)-2,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1628442-67-0)
Recommended Standards
- 3-{[(5-bromothiophen-2-yl)methyl]sulfanyl}-4-methyl-4,5-dihydro-1h-1,2,4-triazol-5-one (CAS 1248942-93-9)
- 6-Bromo-2-(4-methylpiperazin-1-yl)quinoline (CAS 124783-03-5)
- tert-butyl 3-bromo-1H-pyrazolo[3,4-b]pyridine-1-carboxylate (CAS 1234616-46-6)
- 4-Bromo-2-(((3,5-dimethylphenyl)amino)methyl)phenol (CAS 1232806-17-5)
- Fmoc-Dap(Dde)-OH (CAS 247127-51-1)
- Ethyl 6-nitro-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylate (CAS 2407339-51-7)
- n-((5-Sulfamoylthiophen-2-yl)methyl)propionamide (CAS 1099052-73-9)
- 2-{2-[(3-Chloro[1,1-biphenyl]-4-yl)oxy]-ethyl}piperidine hydrochloride (CAS 1219967-46-0)
- 4-(2-Hydroxyethyl)-5-methyl-2-phenyl-1-((2-(2,2,2-trifluoroacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)sulfonyl)-1,2-dihydro-3H-pyrazol-3-one (CAS 861207-34-3)
- (R)-3-(4-Fluorophenoxy)pyrrolidine Hydrochloride (CAS 1314419-67-4)
- (+/-)-5-Methylnicotine (CAS 82111-06-6)
- Leflunomide Impurity 19 (CAS 51135-73-0)
- 2-(Difluoromethyl)-6-hydroxy-5-iodopyridine-3-acetic acid (CAS 1805537-00-1)
- Peptide YY (13-36) (canine, mouse, porcine, rat) (CAS 86895-09-2)
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