3-Methoxy-4-(trifluoromethoxy)phenol CAS 1261571-61-2
| CAS No. | 1261571-61-2 |
| Molecular Formula | C8H7F3O3 |
| Molecular Weight | 208.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 3-Methoxy-4-(trifluoromethoxy)phenol (CAS 1261571-61-2), a certified reference material (molecular formula C8H7F3O3, MW 208.13 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-Methoxy-4-(trifluoromethoxy)phenol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 208.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F3O3 |
| Molecular Weight | 208.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Methoxy Standards
- 3-Methoxy-5-(trifluoromethoxy)phenol (CAS 1261752-88-8)
- 2-Methoxy-4-(trifluoromethoxy)phenol (CAS 166312-49-8)
- 2-Methoxy-5-(trifluoromethoxy)phenol (CAS 895572-36-8)
- (5-Methoxy-3-(trifluoromethyl)pyrazin-2-yl)methanol (CAS 2770349-34-1)
- 5-Methoxy-3-methyl-4-nitro-1,2-benzoxazole (CAS 1435059-44-1)
- 2-(6-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)acetic acid (CAS 1785419-96-6)
- 6-Methoxy-5-nitroisoindolin-1-one (CAS 1822668-04-1)
- 2-(6-Methoxy-9H-purin-9-yl)acetic acid (CAS 6298-52-8)
Recommended Standards
- 4-(Hydroxymethyl)-3-(trifluoromethoxy)phenol (CAS 1232911-86-2)
- 4-(Hydroxymethyl)-2-(trifluoromethoxy)phenol (CAS 1261679-57-5)
- 3,7-Dinitro-1H-pyrrolo[3,2-b]pyridine (CAS 1190313-71-3)
- 5-Nitro-1H-benzo[d][1,2,3]triazole-7-carboxylic acid (CAS 117886-75-6)
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