Bromhexine impurity 57 CAS 1261684-10-9
| CAS No. | 1261684-10-9 |
| Molecular Formula | C7H7BrClN |
| Molecular Weight | 220.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bromhexine impurity 57.
As a process- or degradation-related impurity, Bromhexine impurity 57 (CAS 1261684-10-9, C7H7BrClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Bromhexine impurity 57 (C7H7BrClN) is characterized by a nitrile group, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Bromhexine impurity 57 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H7BrClN |
| Molecular Weight | 220.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromhexine Standards
- Bromhexine impurity 60 (CAS 1261676-18-9)
- Bromhexine EP Impurity C (CAS 57365-08-9)
- Bromhexine Impurity 23 (CAS 30273-41-7)
- Bromhexine EP Impurity B (CAS 50910-55-9)
- Bromhexine Impurity N2 (CAS 63471-27-2)
- Bromhexine EP Impurity D (CAS 132004-28-5)
- Bromhexine Impurity 22 (CAS 114059-99-3)
- Bromhexine Impurity 51 (CAS 100669-82-7)
Recommended Standards
- 5-Bromo-2-chloro-3-methylaniline (CAS 611235-28-0)
- 5-Bromo-2-chloro-3,4-dimethylpyridine (CAS 2272958-66-2)
- (5-chlorobenzothiophen-2-yl)boronic acid (CAS 867381-22-4)
- 5-(2-Bromoethyl)-2-chloropyridine (CAS 369610-28-6)
- Ebastine Impurity 16 (CAS CATO-C4X-202916)
- Ceftaroline Impurity 17 (CAS CATO-C4X-148317)
- SAR107375E Impurity 7 (CAS 5877-96-3)
- 1-[4-(phenylamino)piperidin-1-yl]ethan-1-one (CAS 1157294-82-0)
- Ethyl 3-(1-(4-methyl-1h-pyrazol-1-yl)propan-2-yl)-1,2,4-oxadiazole-5-carboxylate (CAS 1170042-55-3)
- N-(4-(Benzo[d]thiazol-2-yl)-3-chlorophenyl)-7-chloroquinolin-4-amine (CAS 920520-07-6)
- 5-(Tert-butoxycarbonyl)-8-oxo-5-azaspiro[2.5]Octane-1-carboxylic acid (CAS 2387599-49-5)
- (R)-(9H-Fluoren-9-yl)methyl (1-hydroxy-4-(methylthio)butan-2-yl)carbamate (CAS 215178-42-0)
- 8-Fluoroimidazo[1,2-a]pyridin-2-amine (CAS 1781129-93-8)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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