Bromhexine Impurity 51 CAS 100669-82-7
| CAS No. | 100669-82-7 |
| Molecular Formula | C7H6Br2ClN |
| Molecular Weight | 299.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Bromhexine Impurity 51 (CAS 100669-82-7) is a certified pharmaceutical impurity reference standard with the molecular formula C7H6Br2ClN and a molecular weight of 299.39 g/mol.
Owing to a nitrile group, chlorine/bromine substitution, an aromatic ring system, Bromhexine Impurity 51 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 299.39 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H6Br2ClN |
| Molecular Weight | 299.39 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | Technical Grade |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromhexine Standards
- Bromhexine EP Impurity D (CAS 132004-28-5)
- Bromhexine Impurity N2 (CAS 63471-27-2)
- Bromhexine Impurity 34 (CAS 606-00-8)
- Bromhexine Impurity 38 (CAS CATO-C4X-106038)
- Bromhexine EP Impurity B (CAS 50910-55-9)
- Bromhexine Impurity 7 (CAS 1631131-52-6)
- Bromhexine Related Compound 2 (CAS 32193-43-4)
- Bromhexine Impurity 23 (CAS 30273-41-7)
Recommended Standards
- Tert-butyl (4-methylbenzyl)(methylsulfonyl)carbamate (CAS 338415-72-8)
- Omeprazole Impurity 36 (CAS 704910-89-4)
- Omeprazole Impurity 53 (CAS 73590-87-1)
- N-Nitroso Promethazine EP Impurity C (CAS 94511-44-1)
- Pregabalin Impurity 124 (CAS CATO-C4X-1312124)
- Bromocriptine EP Impurity D (CAS 478-83-1)
- Perampanel Impurity 38 (CAS 142929-10-0)
- 2-Chloro-3-formyl-4-picoline (CAS 884495-45-8)
- N-(3-(tert-butyl)bicyclo[1.1.1]Pentan-1-yl)pivalamide (CAS 1886967-04-9)
- N-Acetyl-3-chloropropanohydrazide (CAS 858208-76-1)
- 4-(2-Hydroxyethoxy)benzaldehyde (CAS 22042-73-5)
- Iguratimod Impurity 151 (CAS 500887-53-6)
- 1-([1,1'-Biphenyl]-2-yl)piperazine dihydrochloride (CAS 769944-87-8)
- Insulin Degludec Impurity 13 (CAS CATO-C4X-215713)
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