2-(Difluoromethoxy)-1-fluoro-3-iodobenzene CAS 1261763-19-2
| CAS No. | 1261763-19-2 |
| Molecular Formula | C7H4F3IO |
| Molecular Weight | 288.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Difluoromethoxy)-1-fluoro-3-iodobenzene (CAS 1261763-19-2) is a high-purity analytical reference standard with the molecular formula C7H4F3IO and a molecular weight of 288.01 g/mol.
The molecular framework of 2-(Difluoromethoxy)-1-fluoro-3-iodobenzene (C7H4F3IO) is characterized by a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4F3IO |
| Molecular Weight | 288.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/I-containing |
Related Difluoromethoxy Standards
- 4-(Difluoromethoxy)-2-fluoro-1-iodobenzene (CAS 1261478-98-1)
- 1-(Difluoromethoxy)-2-fluoro-4-iodobenzene (CAS 1261500-62-2)
- 2-(Difluoromethoxy)-1-fluoro-4-iodobenzene (CAS 1261572-00-2)
- 1-(Difluoromethoxy)-3-fluoro-5-iodobenzene (CAS 1261583-29-2)
- 1-(Difluoromethoxy)-3-fluoro-2-iodobenzene (CAS 1261606-77-2)
- 1-(Difluoromethoxy)-2-fluoro-3-iodobenzene (CAS 1261648-85-4)
- 4-(Difluoromethoxy)-1-fluoro-2-iodobenzene (CAS 1261676-10-1)
- 2-(Difluoromethoxy)-4-fluoro-1-iodobenzene (CAS 1261781-73-0)
Recommended Standards
- 1-(Difluoromethoxy)-4-fluoro-2-iodobenzene (CAS 1261827-29-5)
- 5-Iodo-4-(trifluoromethyl)pyridin-2-amine (CAS 1321530-57-7)
- 6-Iodo-2-trifluoromethylphenol (CAS 149209-48-3)
- 2-(Trifluoromethoxy)iodobenzene (CAS 175278-00-9)
- 5-Ethylcarboxamido-2-iodoadenosine (CAS 141018-29-3)
- Phenyldi(pyren-1-yl)phosphine oxide (CAS 721969-93-3)
- Hexamethonium Bromide (CAS 55-97-0)
- 6-(pyrrolidin-1-yl)-2,3-dihydro-1H-indole-2,3-dione (CAS 1146290-05-2)
- (2E,4E)-Methyl 6-bromohexa-2,4-dienoate (CAS 51010-88-9)
- (1R,4R,5R)-1-(thiazol-4-yl)bicyclo[2.1.1]Hexane-5-carboxylic acid (CAS 2227644-92-8)
- 5-Chloro-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 59376-81-7)
- 8-iodo-3-nitro-naphthalene-1-carboxylic acid (CAS 67522-37-6)
- 4-(1-Methylethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 2223035-51-4)
- Retatrutide (CAS 2381089-83-2)
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