Vinorelbine EP Impurity B CAS 126347-74-8
| CAS No. | 126347-74-8 |
| Molecular Formula | C43H52N4O7 |
| Molecular Weight | 736.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Vinorelbine EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Vinorelbine EP Impurity B (CAS 126347-74-8, C43H52N4O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Vinorelbine EP Impurity B (C43H52N4O7) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C43H52N4O7 |
| Molecular Weight | 736.90 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 4 |
Related Vinorelbine Standards
- Vinorelbine Impurity 18 (CAS CATO-C4X-264218)
- Vinorelbine EP Impurity H (CAS 220137-33-7)
- Vinorelbine EP Impurity A (CAS CATO-C4X-26422)
- Vinorelbine Impurity 16 (CAS CATO-C4X-264216)
- Vinorelbine Impurity 17 (CAS CATO-C4X-264217)
- Vinorelbine (CAS 71486-22-1)
- Vinorelbine EP Impurity K (CAS CATO-C4X-264211)
- Vinorelbine EP Impurity J (CAS 38390-45-3)
Recommended Standards
- 4,4'-((1E,1'E)-1,4-Phenylenebis(ethene-2,1-diyl))bis(N,N-bis(4-methoxyphenyl)aniline) (CAS 872466-50-7)
- Nonactin (Mixture contains Monactin and Dinactin) (CAS 6833-84-7)
- (4-(Pyridin-4-yl)-4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepine-2,6-diyl)bis(diphenylmethanol) (CAS 1883396-47-1)
- Ritonavir EP Impurity E (CAS 176655-56-4)
- Prochlorperazine EP Impurity A (CAS 10078-27-0)
- Relugolix Impurity 171 (CAS CATO-C4X-2429171)
- Axitinib Impurity 25 (CAS 2571-90-6)
- 1-amino-4-bromo-1H-pyrrole-2-carbonitrile (CAS 937161-86-9)
- 5-Acetyl-3,3-difluoroindolin-2-one (CAS 1286793-03-0)
- Jasmonic Acid (mixture of isomers) (CAS 221682-41-3)
- 5-(Azetidin-3-yl)-3-(3-methoxyphenyl)-1,2,4-oxadiazole (CAS 1539502-98-1)
- 2-Amino-N-ethyl-3-methylbutanamide hydrochloride (CAS 1236254-95-7)
- 2-(Trifluoromethyl)thiazole-4-carboxylic acid (CAS 915030-08-9)
- Semaglutide impurity 205 (CAS CATO-C4X-2226205)
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