Ritonavir EP Impurity E CAS 176655-56-4
| CAS No. | 176655-56-4 |
| Molecular Formula | C37H48N6O6S2 |
| Molecular Weight | 736.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 736.94 g/mol gives Ritonavir EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ritonavir EP Impurity E (CAS 176655-56-4), a pharmacopoeial impurity reference standard (molecular formula C37H48N6O6S2, MW 736.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Ritonavir EP Impurity E (C37H48N6O6S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H48N6O6S2 |
| Molecular Weight | 736.94 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Ritonavir Standards
- Ritonavir-D10 (CAS 155213-67-5 (unlabeled))
- Ritonavir-d6 (CAS 155213-67-5(unlabelled))
- Ritonavir-13C3 (CAS 1217673-23-8)
- Ritonavir (CAS 155213-67-5)
- Ritonavir EP Impurity G (CAS 2034136-66-6)
- Ritonavir Geo-isomer (CAS 959315-21-0)
- Ritonavir EP Impurity N (CAS 202816-62-4)
- Ritonavir EP Impurity O (CAS 1414933-81-5)
Recommended Standards
- Nonactin (Mixture contains Monactin and Dinactin) (CAS 6833-84-7)
- Difelikefalin Impurity 12 (CAS 2219351-45-6)
- Vinorelbine EP Impurity B (CAS 126347-74-8)
- O-((2R,3R,4R,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl) O-phenyl carbonothioate (CAS 130860-11-6)
- Docetaxel Impurity 57 (CAS CATO-C4X-161957)
- N-Nitroso Metamizole EP Impurity E (CAS CATO-C4X-22639)
- Arbidol Sulfone (CAS 151455-32-2)
- 3-Bromo-5-methoxy-4-(pentyloxy)benzaldehyde (CAS 879643-25-1)
- 2,2,6,6-Tetramethylcyclohexanecarboxylic acid (CAS 13377-52-1)
- 4’-Epi Lamivudine-15N2,13C (CAS 1246815-07-5)
- 2-(2-Furyl)benzimidazole-6-carboxamidoxime (CAS 1965308-71-7)
- Quetiapine EP Impurity K HCl (CAS 1371638-10-6(free base))
- 5-Bromo-2-hydroxyisonicotinaldehyde (CAS 1227562-37-9)
- Myristoyl Pentapeptide-4 (CAS 1392416-25-9)
Why CATO?
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