Calcipotriol Impurity A CAS 126860-84-2
| CAS No. | 126860-84-2 |
| Molecular Formula | C27H40O3 |
| Molecular Weight | 412.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Calcipotriol Impurity A (CAS 126860-84-2, C27H40O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Calcipotriol Impurity A (C27H40O3) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 412.60 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Calcipotriol Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H40O3 |
| Molecular Weight | 412.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
Related Calcipotriol Standards
- Calcipotriol (CAS 112828-00-9)
- Calcipotriol Impurity 13 (CAS 112849-47-5)
- Calcipotriol EP Impurity B (CAS 2948288-30-8)
- Calcipotriol Impurity 25 (CAS CATO-C4X-122225)
- Calcipotriol EP Impurity C (CAS 113082-99-8)
- Calcipotriol (CAS 112965-21-6)
- Calcipotriol EP Impurity D (CAS 112827-99-3)
- Calcipotriol Impurity 41 (CAS CATO-C4X-122241)
Recommended Standards
- [1,1'-Biphenyl]-3-yltriphenylsilane (CAS 13311-13-2)
- SW033291 (CAS 459147-39-8)
- (1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-Cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol (CAS 910133-70-9)
- 3-{[(4-tert-butylphenyl)methyl]sulfanyl}-1-phenyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (CAS 439096-57-8)
- Betahistine Impurity 12 (CAS 109-06-8)
- Methylprednisolone EP Impurity H (CAS 18462-27-6)
- Benproperine Impurity 1 (CAS CATO-C4X-32461)
- Methyl 3-chloroisoquinoline-8-carboxylate (CAS 1432514-94-7)
- Boc-Aminooxy-PEG4-CH2-Boc (CAS 2062663-63-0)
- tert-Butyl 5-chloro-2-(trimethylsilyl)-1H-indole-1-carboxylate (CAS 475102-16-0)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrazole (CAS 1391835-53-2)
- Sisunatovir, >98% (HPLC) (CAS 1903763-82-5)
- 2-Bromo-4-(bromomethyl)-5-(difluoromethyl)-3-(trifluoromethyl)pyridine (CAS 1806858-65-0)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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