Calcipotriol EP Impurity B CAS 2948288-30-8
| CAS No. | 2948288-30-8 |
| Molecular Formula | C27H40O3 |
| Molecular Weight | 412.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Calcipotriol EP Impurity B is closely related to a steroid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Calcipotriol EP Impurity B (CAS 2948288-30-8, C27H40O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Calcipotriol EP Impurity B (C27H40O3) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Calcipotriol EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H40O3 |
| Molecular Weight | 412.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
Related Calcipotriol Standards
- Calcipotriol (CAS 112828-00-9)
- Calcipotriol Impurity A (CAS 126860-84-2)
- Calcipotriol Impurity 13 (CAS 112849-47-5)
- Calcipotriol Impurity 25 (CAS CATO-C4X-122225)
- Calcipotriol EP Impurity C (CAS 113082-99-8)
- Calcipotriol (CAS 112965-21-6)
- Calcipotriol EP Impurity D (CAS 112827-99-3)
- Calcipotriol Impurity 41 (CAS CATO-C4X-122241)
Recommended Standards
- 6870-79-7 Diosgenone (CAS 6870-79-7)
- Sanabo (CAS 912-57-2)
- 2-{[5-(trifluoromethyl)-2-pyridyl]sulphonyl}ethyl 2,3,3-trichloroacrylate (CAS 245072-91-7)
- [1,1'-Biphenyl]-4-yltriphenylsilane (CAS 3172-34-7)
- Ticlopidine Hydrochloride EP Impurity I (CAS 60612-23-9)
- Pemafibrate Impurity 87 (CAS CATO-C4X-290387)
- Dotinurad Impurity 170 (CAS 50910-60-6)
- Methyl N-Boc-4-ethylpiperidine-4-carboxylate (CAS 578021-55-3)
- 5-((Methylamino)methyl)-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (CAS 890647-74-2)
- Ethyl 4-propylpyrimidine-5-carboxylate (CAS 887408-28-8)
- 7-(((1,4-Dioxan-2-yl)methyl)amino)-3-cyclopentylpyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione (CAS 1396810-33-5)
- 2-Cyclopropoxy-6-methoxyaniline (CAS 1243312-36-8)
- Dehydrodivanillin (CAS 2092-49-1)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
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