5-(chlorodifluoromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-4-carboxylic acid CAS 1269151-84-9
| CAS No. | 1269151-84-9 |
| Molecular Formula | C10H5Cl2F2N3O2 |
| Molecular Weight | 308.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
5-(chlorodifluoromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-4-carboxylic acid (CAS 1269151-84-9), molecular formula C10H5Cl2F2N3O2 and molecular weight 308.07 g/mol, is a CATO reference standard with documented purity and traceability.
5-(chlorodifluoromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-4-carboxylic acid (C10H5Cl2F2N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H5Cl2F2N3O2 |
| Molecular Weight | 308.07 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chlorodifluoromethyl Standards
- 5-(Chlorodifluoromethyl)-1-(2-hydroxyethyl)-3-(trifluoromethyl)-1h-pyrazole-4-carboxylic acid (CAS 1421601-49-1)
- 3-(Chlorodifluoromethyl)-6-(pyridin-2-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 477871-73-1)
- 2-(Chlorodifluoromethyl)-4,6-bis(trifluoromethyl)-1,3,5-triazine (CAS 328-77-8)
- 3-(Chlorodifluoromethyl)-6-phenyl-7h-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (CAS 832739-98-7)
- 7-(Chlorodifluoromethyl)-5-methyl-3-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidine (CAS 692733-12-3)
- 7-(Chlorodifluoromethyl)-5-methyl-3-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine (CAS 866049-87-8)
- 5-(Chlorodifluoromethyl)-1-(3-chloropyridin-2-yl)-3-methyl-1h-pyrazole-4-carboxylic acid (CAS 1315366-49-4)
- 5-(chlorodifluoromethyl)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (CAS 1375473-57-6)
Recommended Standards
- Methyl 4-hydroxy-5-iodo-2-methoxybenzoate (CAS 1131587-51-3)
- 5-Iodo-2,3-dimethoxybenzoic acid (CAS 134419-42-4)
- Methyl 2-hydroxy-5-iodo-4-methoxybenzoate (CAS 1131587-46-6)
- 6-Iodo-2-oxohexahydro-2H-3,5-methanocyclopenta[b]furan-7-carboxylic acid (CAS 15573-45-2)
- 2,3-Dichloro-4-fluorobenzyl bromide (CAS 1807053-25-3)
- (S)-1-Cyclohexyl-3-methyl-piperazine oxalate (CAS 1187931-05-0)
- 5-(Pyrrolidin-1-yl)pent-3-yn-1-ol (CAS 550302-87-9)
- 2-Acetamido-3-(7-fluoro-1H-indol-3-yl)propanoic acid (CAS 138471-57-5)
- (3-(Tert-butylcarbamoyl)-4-chlorophenyl)boronic acid (CAS 871332-72-8)
- 3,4,5-Trimethylphenol (CAS 527-54-8)
- 2-{[6-(4-Methylphenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylene}-1H-indene-1,3(2H)-dione (CAS 861213-01-6)
- cis-4-[2-Oxo-2-(3-trifluoromethylphenyl)-ethyl]cyclohexane-1-carboxylic acid (CAS 735275-69-1)
- Aboxitinib Impurity 17 (CAS CATO-C4X-288417)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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