2-(Chlorodifluoromethyl)-4,6-bis(trifluoromethyl)-1,3,5-triazine CAS 328-77-8
| CAS No. | 328-77-8 |
| Molecular Formula | C6ClF8N3 |
| Molecular Weight | 301.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(Chlorodifluoromethyl)-4,6-bis(trifluoromethyl)-1,3,5-triazine.
2-(Chlorodifluoromethyl)-4,6-bis(trifluoromethyl)-1,3,5-triazine (CAS 328-77-8) is a high-purity analytical reference standard with the molecular formula C6ClF8N3 and a molecular weight of 301.52 g/mol.
Owing to a nitrile group, fluorine/chlorine substitution, an aromatic ring system, 2-(Chlorodifluoromethyl)-4,6-bis(trifluoromethyl)-1,3,5-triazine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 301.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6ClF8N3 |
| Molecular Weight | 301.52 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chlorodifluoromethyl Standards
- 3-(Chlorodifluoromethyl)-6-phenyl-7h-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (CAS 832739-98-7)
- 7-(Chlorodifluoromethyl)-5-methyl-3-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidine (CAS 692733-12-3)
- 5-(chlorodifluoromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-4-carboxylic acid (CAS 1269151-84-9)
- 7-(Chlorodifluoromethyl)-5-methyl-3-(pyridin-2-yl)pyrazolo[1,5-a]pyrimidine (CAS 866049-87-8)
- 5-(Chlorodifluoromethyl)-1-(2-hydroxyethyl)-3-(trifluoromethyl)-1h-pyrazole-4-carboxylic acid (CAS 1421601-49-1)
- 3-(Chlorodifluoromethyl)-6-(pyridin-2-ylthio)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 477871-73-1)
- 5-(chlorodifluoromethyl)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (CAS 1375473-57-6)
- 2-(Chlorodifluoromethyl)-5-(trifluoromethoxy)-1H-benzimidazole (CAS 1210386-82-5)
Recommended Standards
- 1-(5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl)-2-chloroethan-1-one (CAS 929972-58-7)
- 2-Bromo-5-chloro-8-hydroxy-7-methylnaphthalene-1,4-dione (CAS 52431-62-6)
- 5-(4-bromo-3-chlorophenyl)-2-furoic acid (CAS 1698596-16-5)
- 3-Bromo-1-(2-chlorophenyl)-1H-pyrazole-5-carboxylic acid (CAS 871239-17-7)
- 1-phenyl-1,2,4-triazolidine-3,5-dione (CAS 6942-46-7)
- 2-(5-(Methoxymethyl)furan-2-yl)-2-oxoacetyl chloride (CAS 107747-90-0)
- 5-Fluoro-2,6-dimethoxynicotinic acid (CAS 2167849-35-4)
- Ethyl 1H-pyrrolo[3,2-b]pyridine-7-carboxylate (CAS 1261542-88-4)
- tert-Butyl 6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 2204252-89-9)
- N-((5-(2-Bromopropanoyl)furan-2-yl)methyl)acetamide (CAS 192431-86-0)
- 5-Methoxypyrazolo[1,5-a]pyridine (CAS 877994-06-4)
- SCH 39166 Hydrobromide (CAS 1227675-51-5)
- N-[(S)-1-(2-Chloro-acetyl)-pyrrolidin-3-yl]-N-methyl-acetamide (CAS 1353945-71-7)
- Tirzepatide Impurity 52 (CAS CATO-C4X-324052)
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