1-Chloro-3-fluoro-2-iodobenzene CAS 127654-70-0
| CAS No. | 127654-70-0 |
| Molecular Formula | C6H3ClFI |
| Molecular Weight | 256.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-Chloro-3-fluoro-2-iodobenzene (C6H3ClFI) is characterized by fluorine/chlorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
1-Chloro-3-fluoro-2-iodobenzene (CAS 127654-70-0) is a high-purity analytical reference standard with the molecular formula C6H3ClFI and a molecular weight of 256.44 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-Chloro-3-fluoro-2-iodobenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3ClFI |
| Molecular Weight | 256.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl/I-containing |
Related Chloro Standards
- 5-Chloro-2-fluoroiodobenzene (CAS 116272-42-5)
- 1-Chloro-3-fluoro-5-iodobenzene (CAS 1270019-81-2)
- 1-Chloro-2-fluoro-6-iodobenzene (CAS 348642-49-9)
- 1-Chloro-4-fluoro-2-iodobenzene (CAS 202982-68-1)
- 4-Chloro-2-fluoroiodobenzene (CAS 6797-79-1)
- 4-Chloro-3-fluoroiodobenzene (CAS 202982-67-0)
- 2-Chloro-5-iodopyrimidin-4(3H)-one (CAS 1226881-10-2)
- 6-Chloro-5-iodopyrimidin-4-ol (CAS 1384431-15-5)
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