Pantoprazole EP Impurity A CAS 127780-16-9
| CAS No. | 127780-16-9 |
| Molecular Formula | C16H15F2N3O5S |
| Molecular Weight | 399.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Pantoprazole EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Pantoprazole EP Impurity A (CAS 127780-16-9), a pharmacopoeial impurity reference standard (molecular formula C16H15F2N3O5S, MW 399.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Pantoprazole EP Impurity A (C16H15F2N3O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 399.37 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H15F2N3O5S |
| Molecular Weight | 399.37 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Pantoprazole Standards
- Pantoprazole Impurity 5 (CAS 953787-60-5)
- Pantoprazole EP Impurity D (CAS 624742-53-6)
- Pantoprazole EP Impurity F (CAS 721924-06-7)
- Pantoprazole impurity 59 (CAS CATO-C4X-139959)
- Pantoprazole-d6 (CAS 922727-65-9)
- Pantoprazole Impurity 32 (CAS CATO-C4X-139932)
- Pantoprazole impurity 62 (CAS CATO-C4X-139962)
- Pantoprazole Isomer(R) Impurity (CAS 142706-18-1)
Recommended Standards
- 2-(2-((4-Bromobenzyl)thio)thiazol-4-yl)-N-butylacetamide (CAS 953983-55-6)
- (E)-1-[(4-Cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]methanecarbohydrazonoyl cyanide (CAS 337928-35-5)
- 4'-(Pyrrolidin-1-ylsulfonyl)-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261894-46-5)
- (E)-1-[(4-Cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]methanecarbohydrazonoyl cyanide (CAS 337928-27-5)
- Oclacitinib Impurity 41 (CAS CATO-C4X-301841)
- Dipyridamole EP Impurity E (CAS 2365420-11-5)
- Ezetimibe Impurity 77 (CAS CATO-C4X-109877)
- Phenyl L-alaninate (CAS 62056-68-2)
- N-Cyclohexyl-2-nitro-4-(piperidin-1-ylmethyl)aniline (CAS 509094-05-7)
- 4-Methyl-1H-indazole-6-carboxylic acid (CAS 1263378-95-5)
- H-Glu(Abu-OH)-OH (CAS 16869-42-4)
- 1-Methyl-2-nitro-3-(trifluoromethyl)benzene (CAS 92891-23-1)
- tert-Butyl 7’-fluoro-2’-oxo-2’,4’-dihydro-1’H-spiro[piperidine-4,3’-quinoline]-1-carboxylate (CAS 1393330-69-2)
- Antifreeze Polypeptide 6 (winter flounder) trifluoroacetate salt (CAS 122604-16-4)
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