(E)-1-[(4-Cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]methanecarbohydrazonoyl cyanide CAS 337928-35-5
| CAS No. | 337928-35-5 |
| Molecular Formula | C14H8F3N5O2S2 |
| Molecular Weight | 399.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (E)-1-[(4-Cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]methanecarbohydrazonoyl cyanide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(E)-1-[(4-Cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]methanecarbohydrazonoyl cyanide (CAS 337928-35-5), molecular formula C14H8F3N5O2S2 and molecular weight 399.37 g/mol, is a CATO reference standard with documented purity and traceability.
(E)-1-[(4-Cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]-N-[4-(trifluoromethyl)phenyl]methanecarbohydrazonoyl cyanide (C14H8F3N5O2S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8F3N5O2S2 |
| Molecular Weight | 399.37 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related E Standards
- (E)-1-[(4-Cyano-5-methyl-1,2-thiazol-3-yl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]methanecarbohydrazonoyl cyanide (CAS 337928-27-5)
- 2-(2-{[3-Cyano-6-(5-methylfuran-2-yl)-4-(trifluoromethyl)pyridin-2-yl]sulfanyl}acetamido)acetic acid (CAS 903086-53-3)
- 2-((2-Cyano-3-methylbutan-2-yl)amino)-2-oxoethyl 3-(thiophene-2-carboxamido)benzoate (CAS 871554-62-0)
- Ethyl 3-cyano-2-(3-phenoxypropanamido)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylate (CAS 864927-02-6)
- 3-Cyano-6-(3-methoxyphenyl)pyridin-2-yl 2,6-dichlorobenzoate (CAS 303152-22-9)
- 3-Cyano-6-(4-methoxyphenyl)pyridin-2-yl 2,6-dichlorobenzoate (CAS 303152-18-3)
- 4-Cyano-3-fluorophenyl (1r,1's,4R,4'R)-4'-pentyl-[1,1'-bi(cyclohexane)]-4-carboxylate (CAS 94353-27-2)
- 4-{[(E)-2-[4-cyano-3-(2,6-dichlorophenyl)-1,2-oxazol-5-yl]ethenyl]amino}benzoic acid (CAS 338402-64-5)
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