1-Boc-4,4-difluoropiperidin-3-amine CAS 1283718-72-8
| CAS No. | 1283718-72-8 |
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-Boc-4,4-difluoropiperidin-3-amine (C10H18F2N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
1-Boc-4,4-difluoropiperidin-3-amine (CAS 1283718-72-8), molecular formula C10H18F2N2O2 and molecular weight 236.26 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Boc-4,4-difluoropiperidin-3-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Boc Standards
- 2-(4,4-Difluoropiperidin-1-yl)-2-phenylacetonitrile (CAS 1226998-22-6)
- 5-(4,4-Difluoropiperidin-1-yl)-1H-indole (CAS 1779128-05-0)
- 1-Boc-3,3-difluoropiperidin-4-ol (CAS 1209780-71-1)
- (4,4-Difluoropiperidin-1-yl)(piperidin-4-yl)methanone (CAS 1442474-22-7)
- 2-(4,4-Difluoropiperidin-1-yl)-2-phenylethanamine (CAS 1227040-43-8)
- (1-Benzyl-4,4-difluoropiperidin-3-yl)methanol (CAS 1303973-25-2)
- (1-Benzyl-3,3-difluoropiperidin-4-yl)methanol (CAS 1303974-07-3)
- 4-(4,4-Difluoropiperidin-1-yl)-2-methoxyphenylamine (CAS 1233184-63-8)
Recommended Standards
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