Cabotegravir Impurity 1 CAS 1284487-51-9
| CAS No. | 1284487-51-9 |
| Molecular Formula | C14H11F4N |
| Molecular Weight | 269.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Cabotegravir Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Cabotegravir Impurity 1 (CAS 1284487-51-9, C14H11F4N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, Cabotegravir Impurity 1 is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 269.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C14H11F4N |
| Molecular Weight | 269.24 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cabotegravir Standards
- Cabotegravir Impurity 23 (CAS CATO-C4X-287623)
- Cabotegravir Impurity 18 (CAS CATO-C4X-287618)
- Cabotegravir Impurity 7 (CAS CATO-C4X-28767)
- Cabotegravir Impurity 8 (CAS 1646862-21-6)
- Cabotegravir Impurity 6 (CAS CATO-C4X-28766)
- Cabotegravir Impurity 5 (CAS CATO-C4X-28765)
- Cabotegravir Impurity 19 (CAS CATO-C4X-287619)
- Cabotegravir Impurity 3 (CAS CATO-C4X-28763)
Recommended Standards
- Potassium (Fluorosulfonyl)(trifluoromethanesulfonyl)imide (CAS 860653-59-4)
- Probenecid Impurity 10 (CAS 141284-79-9)
- N-(4-Ethylphenyl)-2,3,5,6-tetrafluorobenzenamine (CAS 332903-60-3)
- Parathion-methyl-d6 (CAS 96740-32-8)
- Pivmecillinam Impurity 12 (CAS CATO-C4X-232312)
- Rivaroxaban impurity 174 (CAS CATO-C4X-1090174)
- Pirfenidone Impurity 30 (CAS CATO-C4X-222930)
- rac-trans-Permethrinic Acid (CAS 59042-50-1)
- 3-(2-Thienyl)-1H-pyrazole-5-carbohydrazide (CAS 92352-25-5)
- NMS-P715, >98% (HPLC) (CAS 1202055-32-0)
- Palbociclib Impurity 181 (CAS 2601903-88-0)
- 3-Hydroxyisoxazole-5-carboxylic acid (CAS 13626-60-3)
- (E)-N'-Amino-N''-(benzenesulfonyl)-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}guanidine (CAS 338420-81-8)
- Tirzepatide Impurity 25 X TFA Salt (CAS CATO-C4X-324025)
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