Probenecid Impurity 10 CAS 141284-79-9
| CAS No. | 141284-79-9 |
| Molecular Formula | C8H10F3N3O2S |
| Molecular Weight | 269.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Probenecid Impurity 10.
Probenecid Impurity 10 (CAS 141284-79-9) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10F3N3O2S and a molecular weight of 269.24 g/mol.
Structurally, Probenecid Impurity 10 (C8H10F3N3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 269.24 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H10F3N3O2S |
| Molecular Weight | 269.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Probenecid Standards
- Probenecid EP Impurity B (CAS 723-42-2)
- Probenecid (CAS 57-66-9)
- Probenecid Impurity 9 (CAS 141284-78-8)
- Probenecid Impurity 4 (CAS 1206-37-7)
- Probenecid EP Impurity D (CAS 70190-76-0)
- Probenecid Isopropyl Ester (CAS 70190-78-2)
- Probenecid EP Impurity A (CAS 636-78-2)
- Probenecid Impurity 4 (CAS 126865-08-5)
Recommended Standards
- Cabotegravir Impurity 1 (CAS 1284487-51-9)
- Parathion-methyl-d6 (CAS 96740-32-8)
- Potassium (Fluorosulfonyl)(trifluoromethanesulfonyl)imide (CAS 860653-59-4)
- Methyl 1-(2,2-difluoroethyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1018141-97-3)
- Apremilast impurity 91 HCl (CAS 311310-97-1)
- Etoricoxib Impurity 18 (CAS 1027162-35-1)
- Retigabine impurity 9 (CAS CATO-C4X-13149)
- 1-(Dodecylsulfinyl)dodecane (CAS 2168-96-9)
- 3-amino-N,N-dimethylazetidine-1-sulfonamide hydrochloride (CAS 2044901-88-2)
- 3-(3,4-dimethoxyphenyl)-N-(furan-2-ylmethyl)imidazo[1,2-b]pyridazin-6-amine (CAS 1012344-71-6)
- (S)-TERT-BUTYL 3-(4-NITROPHENOXY)PYRROLIDINE-1-CARBOXYLATE (CAS 218944-23-1)
- 6-((3-Bromophenyl)amino)-6-oxohexanoic acid (CAS 1157037-33-6)
- 1-(2-((Benzyl(ethyl)amino)methyl)pyrrolidin-1-yl)-2-chloroethanone (CAS 1353972-58-3)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
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