Palbociclib Impurity 181 CAS 2601903-88-0

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.2601903-88-0
Molecular FormulaC7H5ClN2O2
Molecular Weight184.58 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Palbociclib Impurity 181 CAS 2601903-88-0 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 184.58 g/mol gives Palbociclib Impurity 181 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Palbociclib Impurity 181 (CAS 2601903-88-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5ClN2O2 and a molecular weight of 184.58 g/mol.

The molecular framework of Palbociclib Impurity 181 (C7H5ClN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Palbociclib Impurity 181 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC7H5ClN2O2
Molecular Weight184.58 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor)
Purity≥95%
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2001
Halogen ContentCl-containing
Nitrogen Atoms2

Related Palbociclib Standards

Recommended Standards

Why CATO?