Diltiazem EP Impurity C HCI CAS 1286126-67-7
| CAS No. | 1286126-67-7 |
| Molecular Formula | C21H24N2O4S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Diltiazem EP Impurity C HCI (CAS 1286126-67-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H24N2O4SHCl and a molecular weight of 436.95 g/mol.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Diltiazem EP Impurity C HCI is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 436.95 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Diltiazem EP Impurity C HCI meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H24N2O4S HCl |
| Molecular Weight | 436.95 g/mol |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Diltiazem Standards
- Diltiazem EP Impurity A HCl (CAS 103532-27-0)
- Diltiazem EP Impurity A HCl (CAS 111188-71-7(free base))
- Diltiazem D4 (CAS 112259-41-3)
- Diltiazem USP Related Compound H HCl (CAS 115992-91-1(Free Base))
- Diltiazem EP Impurity H HCl (CAS 115992-91-1(free base))
- Diltiazem Impurity 9 (CAS 116050-35-2)
- Diltiazem Impurity 23 (CAS 119009-50-6)
- Diltiazem-d3 Hydrochloride (CAS 1217623-80-7)
Recommended Standards
- Dalilesen Impurity 22 (CAS CATO-C4X-301022)
- Nafcillin Impurity 2 (CAS CATO-C4X-33382)
- Meclofenoxate Impurity 6 (CAS CATO-C4X-24696)
- Ethyl 2-Hydroxyethyl Sulfide (CAS 110-77-0)
- 4-{[(2,4-difluorophenyl)amino]methylidene}-3-phenyl-4,5-dihydro-1H-pyrazol-5-one (CAS 338975-68-1)
- 2-(But-2-en-2-yl)-1H-benzo[d]imidazole (CAS 953071-79-9)
- (2R,3S,4S,5R,6R)-6-((S)-1,2-diacetoxyethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (CAS 104486-80-8)
- (4-bromothiophen-2-yl)methanamine (CAS 479090-38-5)
- 2-Pyridylacetic Acid-d4 HCl (CAS 2748471-29-4)
- Tirzepatide Impurity 12 (CAS CATO-C4X-324012)
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