Ezetimibe Ring-Opening Dehydrate Impurity CAS 1292292-63-7
| CAS No. | 1292292-63-7 |
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Ezetimibe Ring-Opening Dehydrate Impurity is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 409.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Ezetimibe Ring-Opening Dehydrate Impurity (CAS 1292292-63-7, C24H21F2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ezetimibe Ring-Opening Dehydrate Impurity meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity ((S)-4-Phenyloxazolidin-2-one) Sodium salt (CAS 200067-49-8)
- Ezetimibe (CAS 163222-33-1)
- Ezetimibe meta-Fluorobenzene Isomer (CAS CATO-C4X-1098127)
- Ezetimibe Lactone Impurity 128 (CAS CATO-C4X-1098128)
- Ezetimibe Impurity 17(SCH59566) (CAS 1296129-15-1)
- Ezetimibe o-Fluorobenzene Isomer (CAS 2743547-96-6)
- Ezetimibe Impurity 3 (CAS CATO-C4X-10983)
- Ezetimibe m-Flouroaniline analog (CAS 1700622-06-5)
Recommended Standards
- S,S,S-Ezetimibe (CAS 1593543-07-7)
- S,S,R-Ezetimibe (CAS 1593543-00-0)
- R,S,R-Ezetimibe (CAS 1376614-99-1)
- R,S,S-EzetimiBe (CAS 1478664-18-4)
- Atomoxetine Impurity 9 (CAS 128036-32-8)
- Relugolix Impurity 191 (CAS CATO-C4X-2429191)
- Iguratimod Impurity 131 (CAS CATO-C4X-1826131)
- N-(2-methoxybenzyl)-4-methylpentan-2-amine (CAS 1021122-39-3)
- 2-Azaspiro[4.4]Nonan-1-one (CAS 1004-51-9)
- 3-(Hydroxymethyl)-3-methylthietane 1,1-dioxide (CAS 2193064-98-9)
- N-Desmethyl Zopiclone-d8 Hydrochloride (CAS 1189719-74-1)
- 3-Hydroxy-1-[5-hydroxy-3-methyl-1-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-4-yl]-2-buten-1-one (CAS 129302-16-5)
- (1,3-Benzodioxol-5-ylmethyl)(4-fluorobenzyl)amine hydrobromide (CAS 1609400-44-3)
- Galanin-Like Peptide (porcine) trifluoroacetate salt (CAS 245114-96-9)
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