Ezetimibe Impurity 17(SCH59566) CAS 1296129-15-1
| CAS No. | 1296129-15-1 |
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ezetimibe Impurity 17(SCH59566).
Ezetimibe Impurity 17(SCH59566) (CAS 1296129-15-1) is a certified pharmaceutical impurity reference standard with the molecular formula C24H21F2NO3 and a molecular weight of 409.43 g/mol.
Ezetimibe Impurity 17(SCH59566) (C24H21F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity ((S)-4-Phenyloxazolidin-2-one) Sodium salt (CAS 200067-49-8)
- Ezetimibe (CAS 163222-33-1)
- Ezetimibe meta-Fluorobenzene Isomer (CAS CATO-C4X-1098127)
- Ezetimibe Lactone Impurity 128 (CAS CATO-C4X-1098128)
- Ezetimibe Ring-Opening Dehydrate Impurity (CAS 1292292-63-7)
- Ezetimibe o-Fluorobenzene Isomer (CAS 2743547-96-6)
- Ezetimibe Impurity 3 (CAS CATO-C4X-10983)
- Ezetimibe m-Flouroaniline analog (CAS 1700622-06-5)
Recommended Standards
- S,S,R-Ezetimibe (CAS 1593543-00-0)
- S,S,S-Ezetimibe (CAS 1593543-07-7)
- R,S,R-Ezetimibe (CAS 1376614-99-1)
- R,R,S-Ezetimibed (CAS 163380-16-3)
- Higenamine Impurity RT16 (CAS CATO-C4X-32041)
- Naloxone Hydrochloride EP Impurity C (CAS 2139253-68-0)
- Indocyanine Green Impurity 2 (CAS CATO-C4X-25032)
- 1-((5,6-Dimethyl-1H-benzo[d]imidazol-1-yl)methyl)-1H-benzo[d][1,2,3]triazole (CAS 305861-56-7)
- 1-[2-(4-fluorophenoxy)ethyl]piperidin-4-amine dihydrochloride (CAS 1334148-29-6)
- 2-{[4-phenyl-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid (CAS 18199-82-1)
- 4-((8-(1H-Imidazol-1-yl)octyl)oxy)aniline (CAS 88138-74-3)
- 3-bromo-4-methylpyridin-2-amine (CAS 40073-38-9)
- ethyl (6Z,9Z,12Z,15Z,18Z)-docosa-6,9,12,15,18,21-hexaenoate (CAS CATO-C4X-280643)
- Tirzepatide Impurity 37 (CAS CATO-C4X-324037)
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