Ezetimibe Impurity 3 CAS CATO-C4X-10983
| CAS No. | CATO-C4X-10983 |
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ezetimibe Impurity 3 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Ezetimibe Impurity 3 (CAS CATO-C4X-10983) is a certified pharmaceutical impurity reference standard with the molecular formula C24H21F2NO3 and a molecular weight of 409.43 g/mol.
Structurally, Ezetimibe Impurity 3 (C24H21F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 409.43 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ezetimibe Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity ((S)-4-Phenyloxazolidin-2-one) Sodium salt (CAS 200067-49-8)
- Ezetimibe (CAS 163222-33-1)
- Ezetimibe meta-Fluorobenzene Isomer (CAS CATO-C4X-1098127)
- Ezetimibe Lactone Impurity 128 (CAS CATO-C4X-1098128)
- Ezetimibe Impurity 17(SCH59566) (CAS 1296129-15-1)
- Ezetimibe Ring-Opening Dehydrate Impurity (CAS 1292292-63-7)
- Ezetimibe o-Fluorobenzene Isomer (CAS 2743547-96-6)
- Ezetimibe m-Flouroaniline analog (CAS 1700622-06-5)
Recommended Standards
- R,S,S-EzetimiBe (CAS 1478664-18-4)
- S,R,R-EzetimiBe (CAS 1478664-02-6)
- R,R,R-Ezetimibe (CAS 1593542-96-1)
- R,S,R-Ezetimibe (CAS 1376614-99-1)
- Abemaciclib Impurity 172 (CAS CATO-C4X-2937172)
- Ibrutinib Impurity 107 (CAS CATO-C4X-1064107)
- Safinamide Impurity 62 (CAS CATO-C4X-159062)
- 1-(2-Bromophenyl)piperidine (CAS 156808-79-6)
- 2-(m-Tolyl)propan-2-amine hydrochloride (CAS 1439897-89-8)
- Ethyl 2-(4-chloropyridin-3-yl)acetate (CAS 197376-44-6)
- 1,2-Dioctanoylglycerol ( Mixture of 1,3-Dioctanoyl Glycerol) (CAS CATO-C1045321)
- 2-{[(2-chlorophenyl)methyl](ethyl)amino}acetic acid hydrochloride (CAS 1572282-39-3)
- N′-(2,5-Difluorophenyl)-N,N-dimethylsulfamide (CAS 866154-25-8)
- Experimental Allergic Encephalitogenic Peptide (CAS 29705-92-8)
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