Cinacalcet Impurity N86 CAS 129254-76-8
| CAS No. | 129254-76-8 |
| Molecular Formula | C10H10BrF3 |
| Molecular Weight | 267.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Cinacalcet Impurity N86 (C10H10BrF3) contains fluorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 267.09 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Cinacalcet Impurity N86 (CAS 129254-76-8, C10H10BrF3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10BrF3 |
| Molecular Weight | 267.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Br-containing |
Related Cinacalcet Standards
- Cinacalcet Impurity N22 (CAS 2302907-04-4)
- Cinacalcet Impurity 22 (CAS 21172-43-0)
- Cinacalcet Impurity 65 (CAS 1860814-97-6)
- Cinacalcet Impurity 67 (CAS 3742-75-4)
- Cinacalcet Impurity 67 (CAS 539855-79-3)
- Cinacalcet Impurity 2 (CAS 27916-89-8)
- Cinacalcet Impurity 77 (CAS 1261456-46-5)
- Cinacalcet Impurity 76 (CAS 849442-21-3)
Recommended Standards
- 1-(4-Bromo-3,5-difluorophenyl)thiourea (CAS 1263376-93-7)
- 1-(2-bromopropyl)-2-(trifluoromethyl)-benZene (CAS 1341420-14-1)
- (2-((tert-butoxycarbonyl)amino)-5-methoxyphenyl)boronic acid (CAS 122832-87-5)
- 1-Bromo-3-isopropyl-5-(trifluoromethyl)benzene (CAS 1369928-03-9)
- Tramadol Impurity 10 (CAS 192384-41-1)
- Atorvastatin Impurity N6 (CAS 807312-27-2)
- Perampanel Impurity 8 (CAS CATO-C4X-24308)
- N1,N2-Bis(2,6-dimethylphenyl)oxalamide (CAS 91325-47-2)
- 4-Chloro-6-(2-chlorobenzyl)pyrimidine (CAS 405930-79-2)
- N-(4-Bromophenyl)-5-methylisoxazole-4-carboxamide (CAS 61643-21-8)
- (Lys(Me)??)-Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) trifluoroacetate salt (CAS 1622085-04-4)
- Sodium 2-hydroxypentanoate (CAS 84176-70-5)
- Sitagliptin Impurity 96 (CAS 1675201-14-5)
- Neuropeptide FF (5-8) (CAS 152050-35-6)
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