(R)-4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one CAS 1294000-89-7
| CAS No. | 1294000-89-7 |
| Molecular Formula | C6H8ClF2NO |
| Molecular Weight | 183.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (R)-4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one.
(R)-4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one (CAS 1294000-89-7), molecular formula C6H8ClF2NO and molecular weight 183.58 g/mol, is a CATO reference standard with documented purity and traceability.
(R)-4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one (C6H8ClF2NO) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (R)-4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8ClF2NO |
| Molecular Weight | 183.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related R Standards
- 4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one (CAS 1294000-88-6)
- 3-chloro-1-(3,3-difluoroazetidin-1-yl)propan-1-one (CAS 1334240-54-8)
- 4-chloro-3,5-difluoropyridine-2-carbaldehyde (CAS 1350648-44-0)
- 2-Chloro-1-(3,3-difluoropyrrolidin-1-yl)ethan-1-one (CAS 1391809-92-9)
- (Z)-1-Chloro-4-(2-nitrovinyl)benzene (CAS 101671-01-6)
- 5-Chloro-3-hydroxyindolin-2-one (CAS 1021047-09-5)
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