4-chloro-3,5-difluoropyridine-2-carbaldehyde CAS 1350648-44-0
| CAS No. | 1350648-44-0 |
| Molecular Formula | C6H8ClF2NO |
| Molecular Weight | 183.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-chloro-3,5-difluoropyridine-2-carbaldehyde (CAS 1350648-44-0) is a high-purity analytical reference standard with the molecular formula C6H8ClF2NO and a molecular weight of 183.58 g/mol.
The molecular framework of 4-chloro-3,5-difluoropyridine-2-carbaldehyde (C6H8ClF2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H8ClF2NO |
| Molecular Weight | 183.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related chloro Standards
- 4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one (CAS 1294000-88-6)
- (R)-4-(2-Chloro-2,2-difluoroethyl)pyrrolidin-2-one (CAS 1294000-89-7)
- 3-chloro-1-(3,3-difluoroazetidin-1-yl)propan-1-one (CAS 1334240-54-8)
- 2-Chloro-1-(3,3-difluoropyrrolidin-1-yl)ethan-1-one (CAS 1391809-92-9)
- (Z)-1-Chloro-4-(2-nitrovinyl)benzene (CAS 101671-01-6)
- 5-Chloro-3-hydroxyindolin-2-one (CAS 1021047-09-5)
- 2-Chloro-5-methoxyphenyl Isocyanate (CAS 1067970-63-1)
- 6-Chloro-3-methoxybenzo[d]isoxazole (CAS 1072903-41-3)
Recommended Standards
- Zinc i-propoxide, 99% (CAS 13282-39-8)
- 4,4-Difluoropiperidine-1-carbonyl chloride (CAS 1240057-29-7)
- 3-Cyano-4-fluorobenzoyl chloride (CAS 519059-08-6)
- 4-Chloro-1-nitro-2-vinylbenzene (CAS 112768-02-2)
- 5-(Quinoxalin-6-ylmethylene)-2-thioxothiazolidin-4-one (CAS 648450-30-0)
- spiro[5H-furo[3,4-b]pyridine-7,4-piperidine] (CAS 909034-77-1)
- 2-((7-Methoxy-4-methylquinazolin-2-yl)amino)-5,6-dimethylpyrimidin-4(3H)-one (CAS 374913-63-0)
- 2-Chloro-3-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)naphthalene-1,4-dione (CAS 1426935-67-2)
- (2S)-2-[(2-Methylphenyl)formamido]propanoic acid (CAS 62108-01-4)
- 1-Methyl-N-(3-methylcyclohexyl)-1H-pyrazol-3-amine (CAS 1183596-52-2)
- 2-Amino-6-fluorohexanoic acid (CAS 368-30-9)
- 4-(Methylsulfamoyl)benzoic acid (CAS 10252-63-8)
- Fluticasone Impurity 42 (CAS CATO-C4X-165042)
- Semaglutide impurity 197 (CAS CATO-C4X-2226197)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com