Isoconazole nitrate EP Impurity B CAS 1305320-62-0
| CAS No. | 1305320-62-0 |
| Molecular Formula | C15H13Cl4NO |
| Molecular Weight | 365.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 365.08 g/mol gives Isoconazole nitrate EP Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Isoconazole nitrate EP Impurity B (CAS 1305320-62-0) is a certified pharmaceutical impurity reference standard with the molecular formula C15H13Cl4NO and a molecular weight of 365.08 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Isoconazole nitrate EP Impurity B is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 365.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H13Cl4NO |
| Molecular Weight | 365.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Isoconazole Standards
Recommended Standards
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- Miconazole EP Impurity C (CAS 67358-54-7)
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- 2-(4-Iodophenoxy)-6-(trifluoromethyl)pyridine (CAS 1227955-16-9)
- Dexrazoxane Impurity 3 (CAS CATO-C4X-20203)
- Crisaborole impurity 156 (CAS CATO-C4X-2021156)
- Tigecycline Impurity 2 (CAS CATO-C4X-18602)
- N-(3-Phenylallylidene)-9H-fluoren-2-amine (CAS 5439-53-2)
- 4-Chloro-2-fluoro-3-methylphenol (CAS 1351668-24-0)
- Guanosine Impurity 6 (CAS 18186-48-6)
- 1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbaldehyde (CAS 83174-90-7)
- 4-Cbz-2-homomorpholinecarboxylic Acid (CAS 1141669-63-7)
- 2-Fluoro-n-hydroxybenzamide (CAS 17512-70-8)
- Neuropeptide VF (124-131) (human) (CAS 311309-27-0)
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