Perindopril Impurity 25 HCl CAS 130982-52-4
| CAS No. | 130982-52-4 |
| Molecular Formula | C19H32N2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Perindopril Impurity 25 HCl is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Perindopril Impurity 25 HCl (CAS 130982-52-4), a pharmacopoeial impurity reference standard (molecular formula C19H32N2O5HCl, MW 404.93 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Perindopril Impurity 25 HCl is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 404.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H32N2O5 HCl |
| Molecular Weight | 404.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Perindopril Standards
- Perindopril Impurity N3 (CAS 1004292-98-1)
- Perindopril T-Butylamine (CAS 107133-36-8)
- Perindopril Impurity N1 (CAS 108507-42-2)
- Perindopril Impurity 1 HCl (CAS 111013-52-6)
- Perindopril EP Impurity L (CAS 111836-22-7)
- Perindopril Acyl-beta-D-Glucuronide (CAS 120398-66-5)
- Perindopril Benzyl Ester (CAS 122454-52-8)
- Perindopril EP Impurity F (CAS 129970-98-5)
Recommended Standards
- Erlotinib Impurity 113 (CAS 587-02-0)
- Vericiguat Impurity 67 (CAS 2755814-39-0)
- Vilanterol Impurity 56 (CAS CATO-C4X-193556)
- 3-(2,4-Dimethoxyphenyl)-1H-pyrazol-5-amine hydrochloride (CAS 502132-61-8)
- 7-Nitro-1,2,3,4-tetrahydroquinolin-4-one (CAS 114417-33-3)
- Dimethyl 5-((2,4,6-trimethylphenyl)sulfonamido)isophthalate (CAS 349402-52-4)
- α-Pyrrolidinovalerophenone HCl (α-PVP HCl) (CAS 5485-65-4)
- 5-(Dimethylamino)-3,4-dihydro-2H-pyrrole-4-thiol (CAS 685082-50-2)
- 4-Iodophenyl carbonochloridate (CAS 1312010-00-6)
- D-[Val]10-Semaglutide (CAS CATO-CPTD788630)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com