2-(4-(Difluoromethyl)-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1310949-77-9
| CAS No. | 1310949-77-9 |
| Molecular Formula | C14H19BF2O3 |
| Molecular Weight | 284.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-(4-(Difluoromethyl)-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-(4-(Difluoromethyl)-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1310949-77-9) is a high-purity analytical reference standard with the molecular formula C14H19BF2O3 and a molecular weight of 284.11 g/mol.
Structurally, 2-(4-(Difluoromethyl)-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (C14H19BF2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.5, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 284.11 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H19BF2O3 |
| Molecular Weight | 284.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethyl Standards
- 2-(3-(Difluoromethyl)-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2304635-41-2)
- 5-(Difluoromethyl)-3-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (CAS 2923542-41-8)
- 6-(Difluoromethyl)-4-iodo-3-methylpyridin-2-amine (CAS 1805013-27-7)
- 5-(Difluoromethyl)-3-iodo-2-methylpyridin-4-amine (CAS 1805132-41-5)
- 3-(Difluoromethyl)-5-iodo-6-methylpyridin-2-amine (CAS 1805210-50-7)
- 2-(Difluoromethyl)-3-iodo-5-methylpyridin-4-amine (CAS 1805211-13-5)
- (2-(Difluoromethyl)-6-iodopyridin-4-yl)methanamine (CAS 1805308-54-6)
- 6-(Difluoromethyl)-2-iodo-3-methylpyridin-4-amine (CAS 1805331-47-8)
Recommended Standards
- Ethyl 2-bromo-6-methyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate (CAS 125208-06-2)
- 2-(4-(Difluoromethoxy)-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1310950-04-9)
- 4-[(3-bromophenyl)methyl]morpholine-3,5-dione (CAS 1250558-73-6)
- 3-(3-Bromophenyl)-5-methyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 1326815-55-7)
- 1,1'-[6,7,9,10,17,18,20,21-Octahydrodibenzo[b,k][1,4,7,10,13,16]hexaoxacyclooctadecin-2,13(or 2,14)-diyl]bis[1-pentanone] (CAS 74966-25-9)
- Pyrazolo[1,5-a]pyridine-2-carbothioic acid amide (CAS 885275-04-7)
- Dimethyl 1,2,3,6,7,8-hexahydro-as-indacene-4,5-dicarboxylate (CAS 51037-20-8)
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- Choline fenofibrate EP Impurity E (CAS 42019-08-9)
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- Tirzepatide Impurity 50 (CAS CATO-C4X-324050)
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