Choline fenofibrate EP Impurity E CAS 42019-08-9
| CAS No. | 42019-08-9 |
| Molecular Formula | C19H19ClO4 |
| Molecular Weight | 346.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Choline fenofibrate EP Impurity E (CAS 42019-08-9), a pharmacopoeial impurity reference standard (molecular formula C19H19ClO4, MW 346.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution, Choline fenofibrate EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 346.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H19ClO4 |
| Molecular Weight | 346.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1969 |
| Halogen Content | Cl-containing |
Related Choline Standards
- Choline Fenofibrate Impurity 27 (CAS CATO-C4X-101827)
- Choline Fenofibrate Impurity 28 (CAS CATO-C4X-101828)
- Choline Fenofibrate Impurity 30 (CAS CATO-C4X-101830)
- Choline Fenofibrate Impurity 31 (CAS CATO-C4X-101831)
- Choline Fenofibrate Impurity 32 (CAS CATO-C4X-101832)
- Choline Fenofibrate Impurity 9 (CAS CATO-C4X-10189)
- Choline Fenofibrate Impurity 10 (CAS CATO-C4X-101810)
- Choline Fenofibrate EP Impurity B (CAS 42017-89-0)
Recommended Standards
- 4-Chloro-2,5-difluoro-5-(5,5-dimethyl-1,3-dioxan-2-yl)valerophenone (CAS 898757-44-3)
- Fenofibrate Impurity 33 (CAS 62809-68-1)
- 2-Chloro-4,5-difluoro-5-(5,5-dimethyl-1,3-dioxan-2-yl)valerophenone (CAS 898757-35-2)
- n-(6-Amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-n-(2-methoxyethyl)propanamide (CAS 1050883-98-1)
- Itopride Impurity 25 (CAS CATO-C4X-137725)
- Evocalcet Impurity 21 (CAS CATO-C4X-248521)
- Naproxen EP Impurity H (CAS 5111-66-0)
- 3-Nitro-p-cresol (CAS 2042-14-0)
- [(4-Methoxyphenyl)methyl]({[(4-methylphenyl)methyl]sulfamoyl})amine (CAS 337924-28-4)
- 2,2'-(1,4-Phenylene)bis(3-phenylacrylonitrile) (CAS 13707-95-4)
- Methyl (3E)-2-[(2,4-dichlorophenyl)formamido]-3-{[(2,6-dichlorophenyl)methoxy]imino}propanoate (CAS 318517-64-5)
- 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(3,4-dichlorophenyl)-1,4-diazepane-1-carboxamide (CAS 1024197-18-9)
- 4,4,5,5-Tetramethyl-2-(1-(4-(trifluoromethyl)phenyl)vinyl)-1,3,2-dioxaborolane (CAS 1361046-91-4)
- Macrocyclic Peptide flaviviridae Viruses InhibitorDISCONTINUED (CAS 1510841-23-2)
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