6-(4-methyl-3-(trifluoromethoxy)phenoxy)pyridin-3-amine CAS 1311138-98-3
| CAS No. | 1311138-98-3 |
| Molecular Formula | C13H11F3N2O2 |
| Molecular Weight | 284.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-(4-methyl-3-(trifluoromethoxy)phenoxy)pyridin-3-amine.
6-(4-methyl-3-(trifluoromethoxy)phenoxy)pyridin-3-amine (CAS 1311138-98-3), molecular formula C13H11F3N2O2 and molecular weight 284.23 g/mol, is a CATO reference standard with documented purity and traceability.
6-(4-methyl-3-(trifluoromethoxy)phenoxy)pyridin-3-amine (C13H11F3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 6-(4-methyl-3-(trifluoromethoxy)phenoxy)pyridin-3-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H11F3N2O2 |
| Molecular Weight | 284.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related methyl Standards
- (4-(4-(Trifluoromethoxy)phenoxy)phenyl)methanol (CAS 1686102-84-0)
- 2-(trifluoromethoxy)ethyl 4-methylbenzenesulfonate (CAS 1897449-20-5)
- 2-((4-(Trifluoromethoxy)phenyl)sulfonyl)acetic acid (CAS 773098-22-9)
- 6-[4-(Trifluoromethoxy)phenyl]pyrazine-2-carboxylic Acid (CAS 1258269-13-4)
- 2-(2-(Trifluoromethoxy)phenyl)pyrimidine-5-carboxylic acid (CAS 1261765-94-9)
- 2-[4-(Trifluoromethoxy)phenyl]pyrimidine-4-carboxylic Acid (CAS 1864059-55-1)
- 2-{5-Oxo-4-[4-(trifluoromethoxy)phenyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetonitrile (CAS 866149-42-0)
- 4-[4-(Trifluoromethoxy)phenyl]pyrimidine-2-carboxylic Acid (CAS 912850-80-7)
Recommended Standards
- 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butyl-d9-amino-ethanone (CAS 129138-59-6)
- 5-(2-Methoxy-5-(trifluoromethyl)phenyl)-6-methylpyridazin-3(2H)-one (CAS 1354819-35-4)
- 6-Nitro-2-(4-nitrophenyl)imidazo[1,2-a]pyridine (CAS 118000-57-0)
- 9-((2S,3S,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-1H-purine-2,6-dione (CAS 1448782-33-9)
- MRE-269-d8 (CAS 1265295-15-5)
- 1-(4-((3-Ethoxypropyl)amino)piperidin-1-yl)ethan-1-one (CAS 897772-26-8)
- Verbenalin (CAS 548-37-8)
- Magnesium phosphate pentahydrate (CAS 10233-87-1)
- 4-(4-(4-Bromophenyl)-5-methyl-1H-pyrazol-3-yl)-4H-1,2,4-triazole (CAS 62537-97-7)
- N-(3-Chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetamide (CAS 1632286-05-5)
- 3,4-Difluoro-5-(trifluoromethoxy)aniline (CAS 1803871-78-4)
- 8-Chloro-1-(2-chlorophenyl)-4-(pyrrolidin-1-yl)-3H-benzo[c]azepine (CAS 81389-23-3)
- Ethyl 6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 121873-01-6)
- Endo-Gly4-Semaglutide (CAS CATO-C4X-222679)
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