5-(2-Methoxy-5-(trifluoromethyl)phenyl)-6-methylpyridazin-3(2H)-one CAS 1354819-35-4
| CAS No. | 1354819-35-4 |
| Molecular Formula | C13H11F3N2O2 |
| Molecular Weight | 284.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(2-Methoxy-5-(trifluoromethyl)phenyl)-6-methylpyridazin-3(2H)-one.
5-(2-Methoxy-5-(trifluoromethyl)phenyl)-6-methylpyridazin-3(2H)-one (CAS 1354819-35-4) is a high-purity analytical reference standard with the molecular formula C13H11F3N2O2 and a molecular weight of 284.23 g/mol.
5-(2-Methoxy-5-(trifluoromethyl)phenyl)-6-methylpyridazin-3(2H)-one (C13H11F3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(2-Methoxy-5-(trifluoromethyl)phenyl)-6-methylpyridazin-3(2H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11F3N2O2 |
| Molecular Weight | 284.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methoxy Standards
- 3-Methoxy-6-methyl-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one (CAS 146824-75-1)
- 1-(2-methoxy-2-methyl-propyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole (CAS 1298032-47-9)
- 2-(2-Methoxy-5-methyl-3-nitrophenyl)-2H-benzo[d][1,2,3]triazole (CAS 122652-15-7)
- N-(7-Methoxy-3-oxo-3H-phenoxazin-2-yl)acetamide (CAS 479686-41-4)
- 2-(3-methoxy-1-naphthyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 627526-33-4)
- 2-(4-methoxy-1-naphthyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 269410-16-4)
- 2-Methoxy-1-naphthaleneboronic acid pinacol ester (CAS 269410-05-1)
- 2-(4-Methoxy-3,5-dimethylbenzoyl)benzoic acid (CAS 1443314-57-5)
Recommended Standards
- 6-(4-methyl-3-(trifluoromethoxy)phenoxy)pyridin-3-amine (CAS 1311138-98-3)
- 9-((2S,3S,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-1H-purine-2,6-dione (CAS 1448782-33-9)
- 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butyl-d9-amino-ethanone (CAS 129138-59-6)
- ethyl 1-[2-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylate (CAS 1461708-18-8)
- 3-(n-Benzyl4-chloro-2-fluorobenzenesulfonamido)propanoic acid (CAS 794584-40-0)
- 4-Methylbenzene-1,3-diol (CAS 496-73-1)
- Phenyl 3-oxobutanoate (CAS 6864-62-6)
- {[4-(2-Dimethylamino-5-trifluoromethyl-pyridin-3-yl)-benzyl]-methyl-amino}-acetic acid ethyl ester (CAS 1311279-16-9)
- Apixaban II (CAS 385425-15-0)
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- Cholecalciferol EP Impurity A (CAS 22350-41-0)
- Methyl 3,4-Diamino-2-methoxybenzoate (CAS 538372-37-1)
- 1-(2-Ethoxyphenyl)-2,5-dimethyl-1H-pyrrole (CAS 124678-42-8)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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