Phenylephrine Impurity 44 CAS 131341-58-7
| CAS No. | 131341-58-7 |
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Phenylephrine Impurity 44 (CAS 131341-58-7, C8H8O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Phenylephrine Impurity 44 (C8H8O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
Related Phenylephrine Standards
- Phenylephrine Impurity 27 (CAS 495-42-1)
- Phenylephrine Impurity 41 (CAS 51674-33-0)
- Phenylephrine Impurity 79 (CAS CATO-C4X-146779)
- Phenylephrine Hydrochloride - Impurity A (Freebase) (CAS 5596-07-6)
- Phenylephrine Impurity 73 (CAS CATO-C4X-146773)
- Phenylephrine Impurity 37 (CAS 70935-14-7)
- Phenylephrine Impurity 88 (CAS CATO-C4X-146788)
- Phenylephrine Impurity 59 (CAS 50700-49-7)
Recommended Standards
- Azathioprine Impurity 21 (CAS 30467-02-8)
- Norepinephrine Impurity 22 (CAS 1197-09-7)
- Deferasirox EP Impurity F (CAS 619-67-0)
- Atomoxetine Hydrochloride EP Impurity E (CAS 17199-29-0)
- Clopidogrel Impurity 90 (CAS 1251736-86-3)
- Gefitinib Impurity 30 (CAS CATO-C4X-111730)
- Tamsulosin Impurity 38 (CAS 116091-64-6)
- Selexipag Impurity 8 (CAS CATO-C4X-19618)
- (2-(1-Methyl-1H-pyrazol-4-yl)tetrahydrofuran-3-yl)methanamine (CAS 1423034-27-8)
- n-(Cyclopropylmethyl)-3-fluoro-5-methylaniline (CAS 1500978-29-9)
- 2-Methoxy-1-(2-(piperidin-4-yl)azepan-1-yl)ethan-1-one (CAS 1311316-72-9)
- n-Benzyl-2-chloro-n-(2-phenylethyl)propanamide (CAS 731011-97-5)
- (S)-1-(2-nitrophenyl)ethan-1-amine (CAS 198756-82-0)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
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