Sitafloxacin Impurity 38 CAS CATO-C4X-115538
| CAS No. | CATO-C4X-115538 |
| Molecular Formula | C20H18ClF2N3O4 |
| Molecular Weight | 437.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sitafloxacin Impurity 38 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Sitafloxacin Impurity 38 (CAS CATO-C4X-115538) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18ClF2N3O4 and a molecular weight of 437.82 g/mol.
The molecular framework of Sitafloxacin Impurity 38 (C20H18ClF2N3O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sitafloxacin Impurity 38 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H18ClF2N3O4 |
| Molecular Weight | 437.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Sitafloxacin Standards
- Sitafloxacin impurity 81 (CAS CATO-C4X-115581)
- Sitafloxacin-D4 (CAS CATO-C4X-115552)
- Sitafloxacin Impurity 28 (CAS CATO-C4X-115528)
- Sitafloxacin Isomer Impurity 3(SSR) (CAS 127254-11-9)
- Sitafloxacin Isomer Impurity 4(RSR) (CAS 127199-06-8)
- Sitafloxacin Isomer Impurity (RRR) (CAS CATO-C4X-11555)
- Sitafloxacin impurity 58 (CAS CATO-C4X-115558)
- Sitafloxacin Isomer Impurity 6(SRR) (CAS CATO-C4X-11556)
Recommended Standards
- 2-[(2-Chloro-6-fluorophenyl)methyl]-4-[(1E)-({[3-(trifluoromethyl)phenyl]methyl}imino)methyl]benzene-1,3-diol (CAS 341967-52-0)
- Tris(decyl)amine (CAS 1070-01-5)
- 1-{1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-indol-3-yl}-2-(morpholin-4-yl)ethane-1,2-dione (CAS 338409-89-5)
- (E)-Methyl 2-(2-((6-(4-chloro-2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate (CAS 131860-80-5)
- Selexipag Impurity 57 (CAS CATO-C4X-196157)
- Spironolactone Impurity 20 (CAS CATO-C4X-134520)
- Relugolix Impurity 80 (CAS CATO-C4X-242980)
- 2-Chloro-4-methoxy-3-methylaniline (CAS 2060044-86-0)
- Methyl 2-3-6-tri-O-benzoyl-4-O-trifluoromethanesulfonyl-α-D-galactopyranoside (CAS 79580-70-4)
- Methyl 5-((2-fluorophenyl)carbamoyl)-4-methyl-2-(thiophene-2-carboxamido)thiophene-3-carboxylate (CAS 335409-92-2)
- N-(2-Benzoyl-4-chlorophenyl)-2-{[(1S)-1-phenylethyl]amino}acetamide (CAS 1616506-46-7)
- 2-Bromo-6-fluorobenzaldehyde oxime (CAS 1309606-36-7)
- 2-(5Z)-5-Tetradecen-1-yl-cyclobutanone (CAS 173074-85-6)
- Influenza PR8 Hemagglutinin Peptide (110-119) (H-6312.0005) (CAS 132031-50-6)
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