Trimethoprim EP Impurity B CAS 30806-86-1
| CAS No. | 30806-86-1 |
| Molecular Formula | C14H16N4O4 |
| Molecular Weight | 304.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trimethoprim EP Impurity B.
CATO supplies Trimethoprim EP Impurity B (CAS 30806-86-1), a pharmacopoeial impurity reference standard (molecular formula C14H16N4O4, MW 304.30 g/mol) used for the identification and quantification of trace impurities in APIs.
Trimethoprim EP Impurity B (C14H16N4O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Trimethoprim EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H16N4O4 |
| Molecular Weight | 304.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 4 |
Related Trimethoprim Standards
- Trimethoprim EP Impurity A (CAS 213745-86-9)
- Trimethoprim Impurity 12 (CAS 92653-78-6)
- Trimethoprim EP Impurity G (CAS 78025-68-0)
- Trimethoprim N-Oxide 1 (CAS 27653-68-5)
- Trimethoprim N-Oxide 3 (CAS 27653-67-4)
- Trimethoprim EP Impurity C (CAS 29606-06-2)
- Trimethoprim-d9 (CAS 1189460-62-5)
- Trimethoprim-d3 (CAS 1189923-38-3)
Recommended Standards
- Tropisetron Impurity 2 (CAS CATO-C4X-11792)
- Letrozole Impurity 10 (CAS CATO-C4X-182910)
- Ibrutinib Impurity 180 (CAS CATO-C4X-1064180)
- Letrozole Impurity 31 (CAS CATO-C4X-182931)
- Mitiglinide impurity 22 (CAS CATO-C4X-116122)
- Dalbavancin Impurity 22 (CAS CATO-C4X-160222)
- Memantine impurity 47 (CAS 90812-21-8)
- 1,2-Bis(phenylsulfinyl)ethane (CAS 6099-21-4)
- Bazedoxifene-d4 Acetate (CAS 1795027-71-2)
- 2-(5-Chloropentyl)furan (CAS 92638-97-6)
- 3-Amino-5-iodopyridin-4-ol hydrochloride (CAS 1332581-59-5)
- 6-(sec-Butoxy)-2-(o-tolylthio)pyrimidin-4-amine (CAS 284681-45-4)
- N-Butyl ethyl sulfide (CAS 638-46-0)
- [Glu]17-Liraglutide (CAS CATO-C4X-199236)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com