4-(2-Fluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid CAS 1326810-05-2
| CAS No. | 1326810-05-2 |
| Molecular Formula | C18H23FN2O4 |
| Molecular Weight | 350.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(2-Fluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid.
4-(2-Fluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326810-05-2) is a high-purity analytical reference standard with the molecular formula C18H23FN2O4 and a molecular weight of 350.38 g/mol.
The molecular framework of 4-(2-Fluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (C18H23FN2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H23FN2O4 |
| Molecular Weight | 350.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluorobenzoyl Standards
- 4-(3-Fluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326809-41-9)
- 4-(4-Fluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326810-99-4)
- 4-(4-Fluorobenzoyl)-N-(4-methoxybenzyl)-1H-pyrrole-2-carboxamide (CAS 439111-54-3)
- Ethyl 2-[(2-fluorobenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS 307342-15-0)
- 6-(4-Fluorobenzoyl)-7-thia-1,9-diazatetracyclo[9.2.2.0^{2,10}.0^{4,8}]pentadeca-2(10),3,5,8-tetraen-5-amine (CAS 939888-43-4)
- 2-(4-(4-Fluorobenzoyl)phenyl)-2-(4-methoxyphenyl)acetonitrile (CAS 339114-73-7)
- 3-{2-[(2-Fluorobenzoyl)amino]phenoxy}-2-thiophenecarboxylic acid (CAS 900019-03-6)
- Ethyl 2-(4-(4-fluorobenzoyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)acetate (CAS 439112-17-1)
Recommended Standards
- Dimethyl-{6-[3-(5-methyl-1H-pyrazol-3-yl)-phenyl]-4-trifluoromethyl-pyridin-2-yl}-amine (CAS 1311277-98-1)
- Tert-butyl 4-(((4-fluorobenzo[d]isoxazol-3-yl)oxy)methyl)piperidine-1-carboxylate (CAS 1331782-33-2)
- Di-tert-butyl (4-cyano-2-fluorobenzyl)iminodicarbonate (CAS 1196152-39-2)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrazole (CAS 1334400-08-6)
- (S)-2-((S)-2,6-Diaminohexanamido)-3-methylbutanoic acid hydrochloride (CAS 92218-55-8)
- 1-((1-(5-Methylfuran-2-yl)ethyl)amino)propan-2-ol (CAS 1154997-04-2)
- 2-(2-fluoro-4-methylbenzenesulfonamido)acetic acid (CAS 1803595-47-2)
- 2-Isopropyl-2,5-dimethyl-2,3-dihydrofuran (CAS 131532-55-3)
- 1-(4-Chlorophenyl)-3-[(4-methoxyphenyl)sulfanyl]propan-1-one (CAS 320422-67-1)
- endo-BCN-PEG3-NH-Boc (CAS 1807501-84-3)
- Sofosbuvir Impurity 123 (CAS 119804-96-5)
- 1-Allyl-2-(4-bromophenyl)piperidine (CAS 885274-86-2)
- 1-(2,4-Difluorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde (CAS 618101-85-2)
- Peptide T (CAS 106362-32-7)
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