Rifampicin Impurity 8 CAS 13292-45-0
| CAS No. | 13292-45-0 |
| Molecular Formula | C42H56N4O12 |
| Molecular Weight | 808.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Rifampicin Impurity 8 (CAS 13292-45-0), a pharmacopoeial impurity reference standard (molecular formula C42H56N4O12, MW 808.91 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Rifampicin Impurity 8 (C42H56N4O12) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 808.91 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C42H56N4O12 |
| Molecular Weight | 808.91 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Nitrogen Atoms | 4 |
Related Rifampicin Standards
- Rifampicin Impurity R1 (CAS CATO-C4X-14570)
- Rifampicin EP Impurity A (CAS 13983-13-6)
- Rifampicin Impurity 6 (CAS 1416773-22-2)
- Rifampicin (CAS 13292-46-1)
- Rifampicin-d3 (CAS 1262052-36-7)
- Rifampicin-d8 (CAS CATO-CCAD303670)
- Rifampicin impurity 11 (CAS CATO-C4X-145611)
- Rifampicin Impurity 4 (CAS 16783-99-6)
Recommended Standards
- 27-(demethyl) Rifampicin (CAS CATO-C4X-145612)
- N2-DMF-9-(2-deoxy-5-O-DMT-β-D-ribofuranosyl)purine 3-CE phosphoramidite (CAS 178925-41-2)
- Velpatasvir Impurity 4 (CAS CATO-C4X-28944)
- Cefmetazole Impurity 74 (CAS CATO-C4X-150774)
- Hydroxychloroquine Impurity 46 (CAS CATO-C4X-183546)
- Oseltamivir Impurity 109 (CAS CATO-C4X-1720109)
- Pranlukast Impurity N1 (CAS 136450-11-8)
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- Methyl 1-(chlorosulfonyl)imidazo[1,5-a]pyridine-6-carboxylate (CAS 2126161-95-1)
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