Rifampicin Impurity 4 CAS 16783-99-6
| CAS No. | 16783-99-6 |
| Molecular Formula | C41H56N4O11 |
| Molecular Weight | 780.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rifampicin Impurity 4 (CAS 16783-99-6, C41H56N4O11) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rifampicin Impurity 4 (C41H56N4O11) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 780.90 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Rifampicin Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C41H56N4O11 |
| Molecular Weight | 780.90 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 4 |
Related Rifampicin Standards
- Rifampicin Impurity 14 (CAS CATO-C4X-145614)
- Rifampicin Impurity 8 (CAS 13292-45-0)
- Rifampicin Impurity R1 (CAS CATO-C4X-14570)
- Rifampicin EP Impurity A (CAS 13983-13-6)
- Rifampicin Impurity 6 (CAS 1416773-22-2)
- Rifampicin (CAS 13292-46-1)
- Rifampicin-d3 (CAS 1262052-36-7)
- Rifampicin-d8 (CAS CATO-CCAD303670)
Recommended Standards
- 2,4,6,8,10-Pentamethyl-2,4,6,8,10-pentakis(3,3,3-trifluoropropyl)cyclopentasiloxane (~90%) (CAS 2063-78-7)
- Oseltamivir Impurity 72 (CAS CATO-C4X-172072)
- PC Biotin-PEG3-alkyne (CAS 1869922-24-6)
- Oseltamivir Impurity 73 (CAS CATO-C4X-172073)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
- Avatrombopag Impurity 88 HCl (CAS CATO-C4X-223488)
- Resmetirom impurity 65 (CAS 1696366-11-6)
- (R)-2-Methoxy-phenylglycine (CAS 103889-84-5)
- Ethyl 2-(6-bromopyridin-2-yl)acetate (CAS 955369-63-8)
- 3-(Butylthio)-4H-1,2,4-triazole (CAS 23988-55-8)
- 4-Chlorotoluene (CAS 106-43-4)
- 1-(2-Chlorophenyl)-4-hydrazinyl-1H-pyrazolo[3,4-d]pyrimidine (CAS 1310101-46-2)
- 2-Bromo-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-4-one (CAS 2750605-58-2)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
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